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ZHX2的研究进展 被引量：1

Progress in research on ZHX2
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摘要 新型转录抑制因子ZHX2(zinc-fingers and homeoboxes 2,ZHX2)属于锌指和同源框(zinc-fingers and homeoboxes,ZHX)家族,广泛存在于各种组织细胞核内,发挥转录抑制作用。ZHX2与多发性骨髓瘤(multiple mye-loma,MM)和肝细胞癌(hepatocellular carcinoma,HCC)的发生发展密切相关。此外,ZHX2对肾脏疾病发展过程中基因表达的转录调控有重要作用。ZHX2亦参与大脑皮层发育过程中神经前体细胞维持的调控。 Zinc-fingers and homeoboxes 2（ZHX2）,a member of families,exists in the nucleus of various cells and plays an important role in transcriptional repress.ZHX2 is closely related to the genesis and development of multiple myeloma（MM） and hepatocellular carcinoma（HCC）.In addition,ZHX2 regulates gene expression in the development of kidney disease.ZHX2 also acts as a regulator for neural progenitor maintenance in cerebral cortex development.
作者 陈伟露 吕自力
机构地区 广西医科大学病理学教研室
出处 《国际病理科学与临床杂志》 CAS 2010年第4期342-345,共4页 Journal of International Pathology and Clinical Medicine
基金 广西青年科学基金(0728057)~~
关键词 ZHX2 转录抑制因子 调控 zinc-fingers and homeoboxes 2 transcriptional repressor regulation
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Kawata H,Yamada K,Shou Z,et al. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3[J].Gene,2003, 323:133-140.
  • 2Kawata H,Yamada K,Shou Z,et al.Zinc-fingers and homeoboxes(ZHX) 2,a novel member of the ZHX family,functions as a transcriptional repressor[J].Biochem J,2003,373(Pt3):747-757.
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  • 6Morford LA,Davis C,Jin L,et al. The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2[J].Hepatology,2007, 46(5):1541-1547.
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  • 9Armellini A,Sarasquete ME,Garcia-Sanz R,et al. Low expression of ZHX2,but not RCBTB2 or RAN,is associated with poor outcome in multiple myeloma[J].Br J Haematol,2008, 141(2):212-215.
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二级参考文献21

  • 1Jemal A, Murrary T, Ward E, et al. Cancer statistics. CA Cancer J Clin, 2005, 55: 10-30.
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  • 6Mateos MV, Hemandez JM, Hernandez MT, et al.Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a muhicenter phase 1/2 study. Blood, 2006, 108: 2165-2172.
  • 7Rajkumar SV, Jacobus S, Callander N, et al. A randomized trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in newly diagnosed multiple myeloma (E403): a trial coordinated by the Eastern Cooperative Oncology Group. Blood, 2007, 110. Abstract #31.
  • 8Abdelkefi A, Ladeb S, Torjman L, et al. Single autologous stem cell transplantation followed by maintenance therapy with thalidomide is superior to double autologous transplantation in multiple myeloma: results of a muhicenter randomized clinical trial. Blood, 2008, 111: 1805-1810.
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共引文献3

同被引文献9

  • 1Kawata H,Yamada K, Shou Z, et al. fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor[J].Biochem J ,2003 ;373 ( Pt 3 ) :747-57.
  • 2Yamada K, Ogata-Kawata H, Matsuura K, et al. ZHX2 and ZHX3 repress cancer markers in normal hepatocytes [J].Front Biosci, 2009 ; 14 ( I ) : 3724-32.
  • 3Wagner AO, Malin C, Nlmer P. Application of denaturing high performance liquid chromatography in microbial ecology: fermentor sludge, compost and soil community profiling[J]. Appl Environ Microbio1,2009 ;75: 956-64.
  • 4Morford LA, Davis C, Jin L,et al. The oncofetal gene glypican 3 is regulated in the postnatal liver by zinc fingers and homeoboxes 2 and in the regenerating liver by alpha-fetoprotein regulator 2 [J]. Hepatology ,2007 ;46 (5) :1541-7.
  • 5Wu C, Qiu R, Wang J,et al. ZHX2 interacts with ephrin-B and regulates neural progenitor maintenance in the developing cerebral cortex[J]. J Neurosci ,2009 ;29 (23) :7404-12.
  • 6Lv Z, Zhang M, Bi J, et al. Promoter hypermethylation of a novel gene, ZHX2, in hepatocellular carcinoma [J]. Am J Clin Pathol, 2006 ; 125 (5) :740-6.
  • 7Armellini A, Sarasquete ME, Garcia-Sanz R, et al. Low expression of ZHX2, but not RCBTB2 or RAN;is associated with poor outcome in multiple myeloma[J]. Br J Haemato1,2008 ; 141 (2) :212-5.
  • 8Zhong ZD,Hammani K,Bae WS,et al. NF-Y and Sp1 cooperate for the transcriptional activation and cAMP response of human tissue inhibitor of metalloproteinases -2 [J].J Biol Chem, 2000 ; 275 ( 24 ) : 18602 - 10.
  • 9Cappabianca L,Farina AR, Tacconelli A ,et al. Reconstitution of TIMP-2 expression in SH-SY5Y neuroblastoma cells by 5-azacytidine is mediated transcriptionally by NF-Y through an inverted CCAAT site[J].Exp Cell Res ,2003 ;286 (2):209-18.

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国际病理科学与临床杂志
2010年 第4期

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