脑缺血患者的微栓子信号与黏附分子

Microembolic signals and adhesion molecules in patients with cerebral ischemia

不稳定斑块是微栓子的主要来源之一.微栓子信号提示患者存在不稳定斑块,近期易发生脑梗死.一系列黏附分子参与了缺血性脑损伤的炎症反应和脑微循环功能的改变.黏附分子之间的相互作用有利于白细胞黏附、迁移以及血小板聚集,促进炎症反应和血栓形成.最近的研究表明,黏附分子可能参与了微栓子的形成过程.对黏附分子和微栓子进行深入研究,有助于开发新的治疗药物和评价药物治疗的效果,对缺血性脑血管病的防治具有积极意义.

Unstable plaque is one of the major sources of microemboli.The microembolic signals indicate that the patients had unstable plaques and are prone to cerebral infarction recently.A series of adhesion molecules involved in the regulation of inflammatory response and functional changes of cerebral microcirculation during ischemic brain injury.The interaction among the adhesion molecules is conducive to leukocyte adhesion,migration,and platelet aggregation,thereby promoting inflammatory response and thrombosis.Recent studies have indicated that adhesion molecules are closely correlated with the instability of atherosclerotic plaques,which may have involved in the formation process of microemboli.The further study of adhesion molecules and microemboli contributes to implementation of drug intervention.It has a positive significance for the prevention and treatment of cerebral ischemia.