期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

游离DNA检测对肿瘤诊断的意义 被引量：1

Significance of free-DNA detection to tumor diagnosis
原文传递
导出
摘要 肿瘤患者血液、胸腹腔积液、脑脊液等体液中可以检测到游离DNA含量远大于正常人，并且游离DNA表现出与肿瘤组织相同的生物学特性。本文综述游离DNA的部分肿瘤特性，主要是游离DNA甲基化、基因突变和微卫星改变等，介绍游离DNA检测对肿瘤患者的诊断、预后跟判断复发等方面的作用。 Free-DNA exists in body fluid of cancer patients, and the concentration is much higher than that of healthy people, and the free DNA is characteristic of tumor issue. This article makes asummary about the study of free DNA in cancer patients, such as methylation,gene mutation, microsatellite instability （MSI） and loss of heterozygosity（ LOH）. it has important significance for tumor dignosis,assessment of prognosis and recurrence.
作者 吕成林(综述) 施炜(综述) 陈建(审校)
机构地区 南通大学附属医院神经外科外科综合实验室
出处 《国际肿瘤学杂志》 CAS 2010年第7期511-514,共4页 Journal of International Oncology
关键词 肿瘤 血液 DNA Neoplasms Blood DNA
分类号 R714.5 [医药卫生—妇产科学]
  • 相关文献

参考文献18

  • 1van der Vaart M,Pretorius PJ.The origin of circulating free DNA.Clin Chem,2007,53(12):2215.
  • 2Boni L,Cassinotti E,Canziani M,et al.Free circulating DNA as possible tumor marker in colorectal cancer.Surg Oncol,2007,16(Suppl 1):S29-31.
  • 3Schwarzenbach H,Stoehlmacher J,Pantel K,et al.Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer.Ann NY Acad Sci,2008,1137:190-196.
  • 4Catarino R,Ferreira MM,Rodrigues H,et al.Quantification of free circulating tumor DNA as a diagnostic marker for breast cancer.DNA Cell Biol,2008,27(8):415-421.
  • 5Pathak AK,Bhutani M,Kumar S,et al.Circulating cell-free DNA in plasma/serum of lung cancer patients as a potential screening and prognostic tool.Clin Chem,2006,52 (10):1833-1842.
  • 6Leung? WK,To KF,Chu ES,et al.Potential diagnostic and prognostic values of detecting promoter hypermethylation in the serum of patients with gastric cancer.Br J Cancer,2005,92(12):2190-2194.
  • 7Kolesnikova EV,Tamkovich SN,Bryzgunova OE,et al.Circulating DNA in the blood of gastric cancer patients.Ann N Y Acad Sci,2008,1137:226-231.
  • 8Frattini M,Gallino G,Signoroni S,et al.Quantitative analysis of plasma DNA in colorectal cancer patients:a novel prognostic tool.Ann N Y Acad Sci,2006,1075:185-190.
  • 9Papadopoulou E,Davilas E,Sotiriou V,et al.Cell-free DNA and RNA in plasma as a new molecular marker for prostate and breast cancer.Ann N Y Acad Sci,2006,1075:235-243.
  • 10Sakakura C,Hamada T,Miyagawa K,et al.Quantitative analysis of tumor-derived methylated RUNX3 sequences in the serum of gastric cancer patients.Anticancer Res,2009,29(7):2619-2625.

同被引文献9

  • 1陈忠平,周旺宁.我国胶质瘤诊断治疗现状和努力方向[J].中国肿瘤,2005,14(2):78-81. 被引量：33
  • 2Taback B, Hoon DS. Circulating nucleic acids and proteomics of plas- ma/serum : clinical utility. Ann N Y Acad Sci ,2004,1022 : 1-8.
  • 3Liu BL,Cheng JX, Zhang W, et al. Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebro- spinal fluid predicts prognosis of malignant gliomas. Neuro Oncol, 2010,12:540-548.
  • 4Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature, 2001,409 : 860 -921.
  • 5Umetani N, Kim J, Hiramatsu S, et al. Increased integrity of free circu- lating DNA in sera of patients with colorecta! or periampullary cancer : direct quantitative PCR for ALU repeats. Clin Chem,2006,52:1062- 1069.
  • 6Lavon I, Refael M, Zelikovitch B, et al. Serum DNA can define tumor- specific genetic and epigenetic markers in gliomas of various grades. Neuro 0ncol,2010,12 : 173-180.
  • 7何正文,刘运生,方加胜,袁贤瑞,陈立华,夏家辉,曹亚,曹美鸿.p16基因突变在人脑胶质瘤癌变中的作用[J].中华实验外科杂志,1998,15(4):335-336. 被引量：2
  • 8赵文君,潘世扬,马建锋,张炳峰,王芳,徐建,谢而付,黄蕾,夏文颖.食管癌患者血浆循环DNA定量检测及临床特征分析[J].临床检验杂志,2009,27(3):201-203. 被引量：11
  • 9朱贵东,刘福生.溶瘤病毒治疗脑胶质瘤新进展[J].中华神经外科杂志,2010,26(5):472-474. 被引量：9

引证文献1

二级引证文献4

国际肿瘤学杂志
2010年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部