呼肠孤病毒治疗肿瘤研究进展

Advancement of Reovirus-based therapy for cancer

呼肠孤病毒（Reovirus）是一种溶瘤病毒，既可以通过活化Ras通路在肿瘤细胞中特异性增殖，但又很少致病。临床前研究表明呼肠孤病毒对很多不同组织类型肿瘤具有抗肿瘤作用。进一步临床研究证实，局部和全身应用呼肠孤病毒具有良好的安全性，同时单一及联合放、化疗也获得令人鼓舞的抗肿瘤效果。高度的安全性和潜在的抗肿瘤效果，使呼肠孤病毒可能成为治疗恶性肿瘤新载体。

Reovirus,a kind of oncolytic viruses, is seldom pathogenic, hut is selectively able to replicate in cancer ceils through activation of Ras signaling. Pre-clinical studies have demonstrated that treatment with reovirus is associated with significant anticancer activity across a range of tumor types. Further clinical evaluation of reovirus therapy has shown that it is well tolerated when administered locally or systemically. Encouraging anticancer efficacy has been observed with single-agent treatment and in combination with chemotherapy and radiotherapy. High safety and promising efficacy of reovirus has raised hopes that it will become a new anticancer agent.