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FTY720抗肿瘤机制研究进展

Antitumor mechanism of FTY720
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摘要 神经鞘氨醇类似物FTY720通过诱导淋巴细胞凋亡和归巢而表现出良好的免疫抑制效果，可用于器官移植的抗排斥反应以及自身免疫性疾病的治疗。近年研究发现FTY720还能够诱导肿瘤细胞生长停滞和凋亡、抑制肿瘤转移而发挥抗肿瘤潜力。 Sphingosine analogue FTY720 exerts good immune suppressive effect by inducing lymphocytes apoptosis and homing, which can be used for organ transplant rejection as well as anti-autoimmune disease treatment. Recent studies have found that FTY720 plays anti-tumor potential by inducing growth arrest and apoptosis as well as inhibiting tumor metastasis.
作者 张宁(综述) 狄文(审校)
机构地区 上海交通大学医学院附属仁济医院妇产科上海交通大学医学院妇产科学研究所
出处 《国际肿瘤学杂志》 CAS 2010年第7期520-523,共4页 Journal of International Oncology
基金 国际科技合作项目（2006DFA32780）
关键词 肿瘤 信号传导 FTY720 Neoplasms Signal transduction FRY720
分类号 R979.5 [医药卫生—药品]
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参考文献16

  • 1Liu Q,Zhao X,Frissora F,et al.FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.Blood,2008,111 (1):275-284.
  • 2Nagaoka Y,Otsuki K,Fujita T,et al.Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.Biol Pharm Bull,2008,31 (6):1177-1181.
  • 3Neviani P,Santhanam R,Oaks JJ,et al.FTY720,a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.J Clin Invest,2007,117(9):2408-2421.
  • 4Matsuoka Y,Nagahara Y,Ikekita M,et al.A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells.Br J Pharm,2003,138(7):1303-1312.
  • 5Hung JH,Lu YS,Wang YC,et al.FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.Cancer Res,2008,68(4):1204-1212.
  • 6Perrotti D,Neviani P.Protein phosphatase 2A (PP2A),a drugable tumor suppressor in Ph1 (+) leukemias.Cancer Metastasis Rev,2008,27(2):159-168.
  • 7Yasui H,Hideshima T,Raje N,et al.FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.Cancer Res,2005,65(16):7478-7484.
  • 8Lee TK,Man K,Ho JW,et al.FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation.Carcinogenesis,2004,25(12):2397-2405.
  • 9Ng KT,Man K,Ho JW,et al.Marked suppression of tumor growth by FTY720 in a rat liver tumor model:the significance of down-regulation of cell survival Akt pathway.Int J Oncol,2007,30(2):375-380.
  • 10Ubai T,Azuma H,Kotake Y,etal.FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.Anticancer Res,2007,27(1A):75-88.
国际肿瘤学杂志
2010年 第7期

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