摘要
血管生成拟态的机制主要涉及肿瘤细胞基因型的转变、肿瘤细胞与细胞外基质的相互作用、肿瘤细胞分子信号改变。近年来的一些研究表明，肝癌组织中血管生成拟态的存在可能与肝癌的侵袭转移潜能以及较差的临床预后有关。
The term vasculogenic mimicry describes the formation of fluid-conducting channels by high-ly invasive and genetically dysregulated tumor cells. The molecular mechanisms of vasculogenic mimicry may be associated with phenotypically interconversion, tumor-extracellular matrix interactions and abnormality in signal pathway of tumor cells. It is recently discovered that in hepatocellular carcinoma vasculogenic mimicry may be associated with the invasive and metastatic potential of tumor cells, as well as poor clinical outcome. This article reviews the present research progression of vasculogenic mimicry in hepatocellular carcinoma.
出处
《国际肿瘤学杂志》
CAS
2010年第7期536-539,共4页
Journal of International Oncology
基金
国家自然科学基金项目（30972892）
安徽省科技攻关项目（07010302193）
安徽省自然科学基金项目（090413107）
安徽省高校自然科学研究重点项目（KJ2009A178）
安徽省“115”产业创新团队一肝细胞癌转移复发研究团队资助项目
安徽省优秀青年科技基金资助项目（08040106818）
关键词
肝肿瘤
细胞外基质
血管生成拟态
Liver neoplasms
Extracellular matrix
Vasculogenic mimicry
