急性缺血性卒中患者凝血、抗凝活性和血液流变学变化规律的研究

Changes of Blood Coagulation, Anti-Coagulation Activity and Hemorheology after Acute Cerebral Infarction

目的研究急性缺血性卒中患者凝血活性、抗凝活性和血液流变学的变化规律。方法选择40例急性缺血性卒中患者和30例健康体检者,采集静脉血,用血凝仪检测血浆纤维蛋白原(Fibrinogen,Fib)、抗凝血酶川活性(Antithrombin Ⅲ:α,AT—Ⅲ:α),用自动血流变测试仪检测血液流变学的指标。对比两组上述指标的差异。结果缺血性卒中后急性期Fib(4.3±1.6g/L)高于对照组(2.9±1.4g/L),有统计学差异(P<0.01),全血和血浆粘度、红细胞压积、红细胞沉降率高于对照组,均有统计学差异(P<0.05),AT—Ⅲ:α在急性期明显低于对照组,有统计学差异(P<0.01)。结论缺血性卒中急性期Fib升高,血液黏度增加,凝血活性增强及抗凝血活性降低。

Objective To study the changes of blood coagulation activity, anti-coagulation activity and hemorheology in patients with acute cerebral infarction. Methods Venous blood samples were collected from 40 patients with acute cerebral infarction and 30 healthy individuals, to examine the levels of Fib, AT-Ⅲ：α with blood coagulation analyzer and hemorheology indexes with automatic hemorheology instrument and to compare the differences between the two groups. Results Fibrinogen（Fib） of the acute cerebral infarction group（4.3±1.6g/L） are higher than that of the control group（2.9±1.4g/L）, which has significant difference（P〈0.01）. The whole blood viscosity, plasma viscosity, hematocrit （HCT） and erythrocyte sedimentation rate （ESR） of the acute cerebral infarction group are higher than those of the control group,which has significant difference （P〈0.05）, AT-Ⅲ：α decreases obviously at acute stage of cerebral infarction, which has significant difference also（P〈0.01）. Conclusion After acute cerebral infarction, Fib and blood viscosity increase, blood coagulant activity increases and anticoagulant activity decreases.