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人CD4分子及其治疗性抗体的研究进展 被引量：4

Advance in Research on Human CD4 Molecule and Anti-CD4 Therapeutic Antibodies
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摘要 在正常情况下,人CD4分子能协助机体免疫系统进行免疫防御、免疫自稳和免疫监视;但在一定条件下,又与某些疾病的发生发展密切相关。目前,已研制出几种抗CD4治疗性抗体,并在一些疾病的临床研究中获得了成效。本文就人CD4分子的结构、功能、与疾病的关系以及抗CD4治疗性抗体的研究进展作一综述。 Normally, human CD4 molecule can aid the immune system with immune defense, immune homeostasis and immune surveillance. Under some abnormal circumstance, however, it closely correlates with the occurrence and progression of some diseases. At present, several therapeutic antibodies against CD4 molecule have been developed, and certain achievements have been made in clinical study on some diseases. This paper reviews the advances in research on the structure and function of human CD4 molecule, the relationship between CD4 molecule and some diseases as well as anti-CD4 therapeutic antibodies.
作者 胡迪超 张爱华 杨晓明
机构地区 武汉生物制品研究所
出处 《中国生物制品学杂志》 CAS CSCD 2010年第8期896-900,共5页 Chinese Journal of Biologicals
关键词 抗原 CD4 分子结构 功能 疾病 抗体 Antigen CD4 Molecular structure Function Disease Antibody
分类号 R392.11 [医药卫生—免疫学]
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参考文献37

  • 1Troadec S, Chentouf M, Cerutti M, et al. In vitro antitumoral activity of baculovirus-expressed chimeric recombinant anti-CD4 anti- body 13B8. 2 on T-cell lymphomas [J]. J Immunother, 2007, 30 (2): 190-202.
  • 2Presta LG. Engineering of therapeutic antibodies to minimize immunogenicity and optimize function [J]. Adv Drug Deliv Rev, 2006, 58 (5-6): 640-656.
  • 3Ansari-Lari MA, Muzny DM, Lu J, et al. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 [J]. Genome Res, 1996, 6(4): 314-326.
  • 4Yu M, Wan M, Zhang J, et al. Nucleoprotein structure of the CDd locus: implications for the mechanisms underlying CDd regulation during T cell development [J]. Proc Natl Acad Sci USA, 2008, 105 (10); 3873-3878.
  • 5Sharma D, Balamurali MM, Chakraborty K, et al. Protein minimization of the gpl20 binding region of human CO4 [J]. Biochemistry, 2005, 44 (49): 16192-16202.
  • 6Harrison SC, Wang J, Yan Y, et al. Structure and interactions of CD4 [J]. Cold Spring Harb Symp Quant Biol, 1992,57:541-548.
  • 7肖鹤,黎燕.CD4分子二聚化或寡聚化的研究进展[J].细胞与分子免疫学杂志,2005,21(B03):28-30. 被引量：3
  • 8Moldovan MC, Sabbagh L, Breton G, et al. Triggering of T cell activation via CD4 dimers [J]. J Immunol, 2006,176 (9):5438- 5445.
  • 9Vignali DA, Vignali KM. Profound enhancement of T cell activation mediated by the interaction between the TCR and the D3 domain of CD4 [J]. J Immunol, 1999, 162 (3):1431-1439.
  • 10崔健,肖鹤,冯健男,沈倍奋.CD4分子功能表位及拮抗剂研究进展[J].军事医学科学院院刊,2007,31(2):170-174. 被引量：7

二级参考文献118

  • 1Zand MS, Li Y, Hancock W, et al. Interleukin-2 and interferon-ganmma double knockout mice reject heterotopic cardiac allografts. [ J ]. Transplantation,2000,70(9) : 1378-1381.
  • 2Le Moine A, Surquin M, Demoor F'X, et al. IL-5 mediates eosinophilic rejection of MHC class 11-disparate skin allografts in mice. [J]. J Immunol,1999,163(7) : 3778-3784.
  • 3Barnes EJ, Abdel-Rehim MM, Goulis Y, et al. Applications and limitations of blood eosinophilia for the diagnosis of acute cellular rejection in liver transplantation. [J]. Am J Transplant,2003,3(4):432-438.
  • 4Gu L,Tseng S, Honer RM, et al. Control of Th2 polarization by the chemokine monocyte chemoattractant protein-1. [ J ]. Nature, 2000,404 (6776) :407-411.
  • 5Kobuyashi H, Novick AC,Toma H, et al. Chronic antagonism of Mig inhibits cellular infiltration and promotes survival of class 11 MHC disparate skin allomafts. [ J ]. Transplantation, 2002,74(3) : 387-395.
  • 6Hancock WW, Gao W, Csiznmdia V, et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. [J].J Exp Med,2000, 192(10) : 1515-1520.
  • 7Jiankuo M, Xingbing W, Baojun H, et al. Peptide nucleic acid antisense prolongs skin allograft survival by means of blockade of CXCR3 expression directing T cells into graft. [J] .J Immunol,2003,170(3) : 1556-1565.
  • 8Li B, Hartono C, Ding R, et al. Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine. [J]. N Engl J Med,2001,344(13) :947-954.
  • 9Bose A, Inone Y, Kokko KE, et al. Cutting edge: perforin down-regulates CIM and CD8 T cell-mediated immune responses to a transplanted organ.[J]. J Immund,2003,170(4) : 1611-1614.
  • 10Buonocore S, Paulart F, Le Moine A, et al. Dendritic cells oveexpressing CD95 (Fas) ligand elicit vigorous allospecific T-cell responses in vivo.[J]. Blood, 2003,101 (4) : 1469-1476.

共引文献15

同被引文献24

  • 1史良如,陈善华,王中德,谭向阳,欧阳斌,徐辉,吴晓波,封江南,王志友,孙可芳,赵亚杰.武汉(Wu)系列抗入T细胞及其亚群单抗[J].单克隆抗体通讯,1989(2):22-29. 被引量：1
  • 2崔健,肖鹤,冯健男,沈倍奋.CD4分子功能表位及拮抗剂研究进展[J].军事医学科学院院刊,2007,31(2):170-174. 被引量：7
  • 3Troadec S, Chentouf M, C6rutti M, et al. In vitro antitumoral activity of baculovirus-expressed chimeric recombinant anti-CD4 antibody 13B8. 2 on T-cell lymphornas [J]. J Immunother, 2007, 30 (2): 190-202.
  • 4国家食品药品监督管理局.人工淋巴细胞亚群分群试剂(武汉-T4).国药准字S10930009.2003.
  • 5Ruberti F, Cattaneo A, Bradbury A. The use of the RACE method to clone hybridoma eDNA when V region primers fail [J]. J Im- munol Methods, 1994, 173 (1): 33-39,.
  • 6Reichert JM. Antibodies to watch in 2010 [J]. MAbs, 2010, 2 (1): 84-100.
  • 7Reichert JM. Global antibody development trends [J]. MAbs, 2009, 1 (1): 86-87.
  • 8Coloma MJ, Hastings A, Wims LA, et al. Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction [J].J Immunol Methods, 1992, 152 (1): 89-104.
  • 9Liu X, Gorovsky MA. Mapping the 5' and 3' ends of Tetrahymena thermophila mRNAs using RNA ligase mediated amplification of cDNA ends (RLM-RACE). Nucleic Acids Res, 1993, 21 (21) : 4954-4960.
  • 10Knappskog S, Ravneberg H, Gjerdrum C, et al. The level of synthesis and secretion of Gaussia princeps luciferase in trans- fected CHO cells is heavily dependent on the choice of signal peptide [J]. J Biotechnol, 2007, 128 (4): 705-715.

引证文献4

二级引证文献10

中国生物制品学杂志
2010年 第8期

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