抗HIV靶向治疗制剂的研究进展

Progress in Research on Targeted Anti-HIV Therapeutic Agents

抗HIV靶向治疗是利用特异性的运载工具,将可杀伤HIV-1感染靶细胞的生物活性弹头选择性地运送到感染靶细胞部位,通过与靶细胞相结合后内化,杀灭体内残存病毒颗粒和潜伏感染细胞,并修复机体免疫系统,恢复机体正常免疫功能。将靶向治疗作为艾滋病(AIDS)治疗的辅助和补充手段,正成为AIDS一种新型的治疗方法。本文就抗HIV靶向治疗的运载工具及生物活性弹头的研究进展作一综述。

The principle of anti-HIV therapy is selective delivery of bioactive warheads killing the target cells of HIV infection to the infected target cells by a specific vehicle, which is internalized after binding to the target cells then kill the residual virus particles and latently infected cells, repair the immune system and recover the normal function of organism. As an accessory and supplemental therapy, targeted anti-HIV therapy is becoming is novel method for treatment of AIDS. The progresses in research on vehicle and bioactive warheads for targeted anti-HIV therapy are reviewed in this paper.