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骨桥蛋白和血管内皮生长因子-C在肺鳞癌和腺癌中的表达及临床意义 被引量：3

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摘要 目的 探讨骨桥蛋白（OPN）和VEGF-C在肺鳞癌、腺癌中的表达水平与临床病理之间的联系及相互关系.方法 运用免疫组化的方法对57例肺癌组织标本进行OPN和VEGF-C检测.结果 （1）57例肺鳞癌、腺癌中OPN和VEGF-C的阳性表达率分别为61.40%、66.67%.肺鳞癌组和腺癌组OPN和VEGF-C表达差异无统计学意义（P〉0.05）.（2）肺鳞癌、腺癌中OPN和VEGF-C表达与肿瘤淋巴结转移有关（P〈0.05）及肿瘤TNM分期有关（P〈0.01）,而与患者的年龄、性别、吸烟及肿瘤细胞分化程度无关（P〉0.05）.（3）OPN与VEGF-C的表达呈正相关（r=0.3972,P〈0.01）.结论 OPN和VEGF-C在肺鳞癌、腺癌的浸润进展和转移过程中起重要作用,而且可能发挥协同作用.OPN和VEGF-C联合检测可作为判断肺癌患者预后的有用指标.
作者 吴强 姜玲 谭光喜
机构地区 三峡大学第一临床医学院 宜昌市夷陵医院
出处 《中国医师杂志》 CAS 2010年第8期1121-1123,共3页 Journal of Chinese Physician
关键词 骨桥蛋白质/代谢 血管内皮生长因子C/代谢 肺肿瘤/代谢 肿瘤 鳞状细胞/代谢 腺癌/代谢
分类号 R734.2 [医药卫生—肿瘤]
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共引文献5

同被引文献40

  • 1王春红,王秀丽,范哲,顾莲芝,李广生.骨保护素和破骨细胞分化因子在多发性骨髓瘤患者骨髓中的表达[J].临床血液学杂志,2005,18(3):181-183. 被引量：5
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中国医师杂志
2010年 第8期

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