不同颜色光刺激视皮层脑功能成像研究

The study of functional magnetic resonance imaging by different color light stimulating the visual cortex

目的:利用功能性磁共振成像(fMRI)研究不同颜色光的变化在视皮层的信号强度的反应。资料与方法:48名受试者均接受红、绿、蓝3种颜色光的刺激。运用功能成像分析软件(AFNI软件)对原始数据进行处理,计算机自动产生出所选层面的时间信号强度相关图,并用统计学方法对图像进行比较。结果:48名受试者接受刺激后在双侧枕叶视皮层均有兴奋区,绿光刺激的平均血氧水平依赖(BOLD)信号强度比红光刺激增强17.5%左右(P<0.05),而蓝光刺激的平均BOLD信号强度比绿光刺激增强9.6%左右(P<0.05)。同时发现右侧光刺激的平均BOLD信号强度比左侧光刺激增强18%左右(P<0.05),此外脑组织兴奋还见于外侧膝状体、上丘、脑干的顶盖前区、顶叶皮层等。结论:通过对fMRI图像进行统计学分析,证实在光的刺激下枕叶视皮层血流信号增强,3种颜色光刺激中对蓝光最敏感,红光敏感性最弱,并且右侧信号变化比左侧强。

Objective：To study the change of signal strength of visual cortex by stimulating it with different color.Mate-rials and Methods：Forty-eight volunteers accepted the stimulation of red,green and blue light.Functional imaging analysis AFNI software was used for processing the raw data,computer automatically generated time signal intensity curves.And using statistical methods to compare them.Results：Occipital lobe in the district of cortex were excited in 48 cases,the average sig-nal intensity of green stimulation was higher than that of red stimulation by 17.5%（P0.05）,the average signal intensity of blue stimulation was higher than that of green by 9.6%（P0.05）.The average signal intensity on the right was higher than that of the left by 18%（P0.05）.It was discovered that other brain excited areas were also found in the corpus geniculatum lat-erale and superior colliculus,anterior tectum of brain stem,parietal cortex.Conclusion：The statistical analysis of fMRI sug-gests that the signals of occipital lobe cortex is increased through three color stimulation,among them,blue stimulation is the most sensitive,and the change is more obvious in the right side than that in the left side.