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细胞与角膜移植免疫耐受 被引量：1

Cells and immunotolerance of keratoplasty
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摘要 角膜移植术后免疫排斥反应是角膜移植失败的主要原因。免疫耐受是指抗原特异性的免疫无应答。诱导受体产生针对移植物的免疫耐受是彻底克服移植排斥反应的根本方法。角膜移植排斥反应是一个复杂且有多因素参与的过程。多种免疫细胞在抑制角膜移植术后排斥反应、诱导免疫耐受中,发挥着关键作用。因此,我们就近几年通过细胞诱导角膜移植免疫耐受的机制作一综述。 Keratoplasty rejection is the main failure factor of keratoplasty. Immunotolerance is antigen-specific immune non-response. Inducing receptors of the immunotolerance against the graft was the fundamental method to completely overcome the transplant rejection. Kerato-plasty rejection is a complex process. All kinds of immunocytes play a critical role in suppressing rejection and inducing immunotolerance.
作者 刁玉梅 李兵
机构地区 辽宁医学院附属第一医院眼科
出处 《国际眼科杂志》 CAS 2010年第9期1716-1718,共3页 International Eye Science
关键词 角膜移植 免疫耐受 排斥反应 细胞 keratoplasty immunotolerance rejection cell
分类号 R392 [医药卫生—免疫学] R779.65 [医药卫生—眼科]
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参考文献26

  • 1Pleyer U,Schlickeiser S.The taming of the shrew? The immunology of corneal transplantation.Acta Ophthalmol 2009;87(5):488-497.
  • 2Steinman RM,Cohn ZA.Identification of a novel cell type in peritheral lymphoid organs of mice.I.Morphology.quantitation.tissue distribution.J Exp Med 1973;137(5):1142-1162.
  • 3Banchereau J,Steinman RM.Dendritic cells and the control of immunity.Nature 1998;392(6637):245-252.
  • 4Hamrah P,Dana MR.Corneal antigen-presenting cells.Chem Immunol Allergy 2007;92:58-70.
  • 5Raimondi G,Thomson AW.Dendritic cells,tolerance and therapy of organ allograft rejection.Contrib Nephrol 2005;146:105-120.
  • 6Nouri-Shirazi M,Thomson AW.Dendritic cells as promoters of transplant tolerance.Expert Opinon Biol Ther 2006;6(4):325-339.
  • 7Khanna A,Morelli AE.Effects of liver-derived dendritic cell progenitors on Th1-and Th2-like cytokine responses in vitro and in vivo.J Immunol 2000;164(3):1346-1354.
  • 8Min WP,Zhou D,Ichim TE,et al.Inhibitort feedback loop between tolerogenic dendritic cells and regulatory T cells in transplant tolerance.J Immunol 2003;170(3):1304-1312.
  • 9Hawiger D,Inaba K.Dendritic cells induce peripheral T cell unresponsiveness under steady conditions in vivo.J Exp Med 2001;194(6):769-779.
  • 10Beutelspacher SC,Pillai R,Watson Mp.Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression.Eur J Immunol 2006;36(3):690-700.

二级参考文献54

  • 1Williams KA, Muehlberg SM, Lewis RF, et al. How successful is corneal transplantation? A report from the Australian corneal graft registe [J]. Eye,1995,9(pt 2) :219 - 227.
  • 2Siebenlist U, Franzoso C, Brown K, et al. Structure, regulatoin and function of NF- κB[J]. Annu Rev Cell Biol,1994,10:405 -455.
  • 3Williams KA, Coster DJ. Penetrating corneal transplantation in the inbred rat: a new model[J]. Invest Ophthalmol Vis Sci, 1985,26(1) :23 - 30.
  • 4Holland EJ. Clinical and immunohistological studies of corneal rejection in the rat penetrating keratoplasty mod[J]. Cornea, 1991, 10(5) :374 - 380.
  • 5Chen FE, Huang DB, Chen YQ, et al. Crystal structure of P50/P65 heterodimer of transcription factor NF - κB bound to DNA[J]. Nature, 1998,391 (22) :410 - 413.
  • 6Yamamoto Y, Gaynor RB. Therapeutic potential of inhibition of the NF - κBpathway in the treatment of inflammation and cancer [J]. J Clin Invest,2001,107(2): 135 - 142.
  • 7Mattson MP, Camandola S. NF- kappaB in neuronal plasticity and neurodegenerative disorders[J]. J Clin Invest. 2001,107(3) :247 - 254.
  • 8Tomita N, Morishita R, Lan HY, et al. In vivo administration of a nuclear transcription factor - kapppaB decoy suppresses experimental crescentic glomerulonephritis[J] .J Am Soc Nephrol, 2000,11 (7): 1244 - 1251.
  • 9KatamiM. Corneal transplantation - immunologically privileged status[J].Eye, 1991,5(pt 5) :528 - 548.
  • 10Streilein JW,Masli S,Takeuchi M,Kezuka T.The eye's view of antigen presentation[J].Hum Immunol 2002,63:435-443.

共引文献3

同被引文献11

  • 1韩波,胡燕华.CTLA4Ig基因修饰的树突状细胞抑制角膜移植排斥反应的机制研究[J].眼科研究,2007,25(5):347-350. 被引量：7
  • 2Lgyarto BZ, Jenison MC. Langerhans cells suppress contact hypersensitive response via cognate CIM interaction and langerhans cell- derived IL-10. J Immunol ,2009;183(8):5085-5093.
  • 3Williams KA, Coster DJ. Penetrating corneal transplantation in the inbred rat: a new model. Invest Ophthalmol Vis Sci 1985 ;26( 1 ):23-30.
  • 4Larkin DFP, Calder VL, Lightman SL. Identification and characterization of cells infiltrating the graft and aqueous humour in rat corneal allograft rejection. Clin Exp lmmunol ,2007 ;107 (2) :381-391.
  • 5Waldmann H. Transplantation tolerance where do we stand. Nat Med ,2009 ;5 : 1245-1248.
  • 6Steinman RM, Cohn ZA. Identification of a novel cell type in peritheral lymphoid organs of mice I Morphology quantitation tissue distribution. J Exp Med 1973 ;137(5) :1142-1162.
  • 7Raimondi G,Thomson AW. Dendritic cells, tolerance and therapy of organ allograft rejection. Contrib Nephrol ,2005 ; 146 : 105-120.
  • 8Liu E, Iw HK, Lau YL. Tolerance associated with cord blood transplantation may depend on the state of host dendritic cells. Br J Hematology ,2004 ; 126:517-526.
  • 9Lgyarto BZ, Jenison MC. Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell- derived IL- 10. J lmmunol ,2009 ; 183 ( 8 ) :5085-5093.
  • 10Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev hnmunol ,2003 ;3 (2) : 133-136.

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国际眼科杂志
2010年 第9期

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