NF-κB(p65)蛋白核转位与唾液腺腺样囊性癌侵袭和转移关系的研究

Translocation of NF-κB p65 may be correlated with the invasion and metastasis of salivary adenoid cystic carcinoma

目的检测NF-κB p65蛋白在唾液腺腺样囊性癌(adenoid cystic carcinoma,ACC)临床组织标本中的表达水平和转位情况,分析其与ACC侵袭和转移之间的关系。方法应用免疫组织化学法,检测58例唾液腺腺样囊性癌石蜡标本中p65蛋白的表达和细胞定位,分析p65蛋白的表达、转位与ACC转移和其他临床病理参数的关系。结果在转移和非转移的ACC组,p65细胞表达阳性率无显著差异(P=0.2641);而p65蛋白的核阳性表达率ACC转移组明显高于非转移组(P=0.0261),并且与ACC神经浸润相关(P=0.0244)。结论 NF-κB通路的激活可能在唾液腺腺样囊性癌侵袭和转移中发挥重要作用。

Objective To examine the expression level of NF-κB p65 protein and its translocation in the tissues of salivary adenoid cystic carcinoma and to analyze their relationship to the invasion and metastasis of ACC. Methods The p65 protein expression was examined in 58 patients with adenoid cystic carcinomas of salivary gland by immunohistochemical staining. The relationship between p65 protein and ACC metastasis and invasion was analyzed. The association between p65 expression levels and the clinicopathological parameters were also examined. Results There was no significant difference of p65 positive rate between the non-metastatic group and the metastatic group. But the p65 nuclear positive rate was higher in the metastatic group than in the non-metastatic group, and the p65 nuclear expression level was related to the ACC invasion. Conclusion NF-κB signal pathway may play an important role in invasion and metastasis of adenoid cystic carcinoma of salivary gland.