C反应蛋白、白细胞和中性粒细胞在新生儿感染中的临床意义

Clinical Significance of C-reactive Protein,Peripheral White Blood Cells and Neutrophillic Granulocyte in Neonatal Infection

目的探讨新生儿感染性疾病中C反应蛋白、白细胞和中性粒细胞的变化及临床意义。方法 352例感染患儿中分为细菌感染组(195例)和病毒感染组(157例),另外选取健康足月儿140例作为正常对照组。所有患儿入院时检测CRP、WBC和GRAN。感染组经过治疗后,于72 h、168 h复查CRP、WBC和GRAN,观察三者的动态变化。结果入院时新生儿细菌感染组CRP、WBC和GRAN均较正常对照组和病毒感染组显著升高(P<0.01)。治疗72和168 h后,细菌感染组CRP、WBC和GRAN明显下降(P<0.01),而病毒感染组各指标变化不明显(P>0.05)。结论新生儿感染中CRP、WBC和GRAN是很好的鉴别细菌与病毒感染的诊断指标,对判断病情变化与疗效具有一定价值。

Objective To investigate the changes and clinical significance of C-reactive protein（CRP）,peripheral white blood cells（WBC） and neutrophilic granulocyte in neonatal bacterial infection.Methods Of 352 newborns with infection,195 suffered from bacterial infection and 157 with viral infection.The venous blood was taken.CRP,WBC and GRAN were determined before the treatment,72 and 168 hours after the anti-infection treatment.The dynamic changes in CRP,WBC and GRAN were recorded.Results The levels of CRP,WBC and GRAN were significantly higher in the bacterial infection group than those in control and the viral infection group（P0.01）.After the anti-infection treatment for 72 and 168 hours,the levels of CRP,WBC and GRAN in the bacterial infection group were reduced rapidly（P0.01）,and there was no significant changes in the viral infection group（P0.05）.Conclusion The levels of CRP,WBC and GRAN are important indicators in differentiating bacteria and virual infection.It is especially useful in the clinical diagnosis of acute respiratory infection in newborns.