缺氧诱导因子-1α在胶质瘤中的表达与意义

Expression and clinical significance of HIF-1α in gliomas

目的探讨缺氧诱导因子-1α(HIF-1α)在胶质瘤中的表达及其临床意义。方法用免疫组化方法分别检测80例胶质瘤中HIF-1α的表达,其中Ⅰ级胶质瘤、Ⅱ级胶质瘤、Ⅲ级胶质瘤、Ⅳ级胶质瘤各20例,以10例瘤周正常脑组织为对照。结果 HIF-1α在Ⅰ、Ⅱ、Ⅲ、Ⅳ级胶质瘤的阳性率分别为20%、50%、75%、95%,在正常脑组织中无表达,各组间有显著差异(χ2=40.26,P<0.01);各级胶质瘤表达强度随胶质瘤病理级别增加而增加(r=0.6977,P<0.001)。HIF-1α表达与患者年龄、性别、肿瘤大小、部位无关。结论 HIF-1α在胶质瘤中的表达强度可以作为判断胶质瘤生物学行为、预测患者预后的重要指标。

Objective To study expression and clinical significance of hypoxia-inducible factor-1α（HIF-1α） in gliomas. Methods A total of 80 glioma tissues were examined for the expression of HIF-1α by immunohistochemical method. Results The positive rate of HIF-1α in gliomas of grade Ⅰ、Ⅱ、Ⅲ and Ⅳ were 20%, 50%, 75% and 95%. There was no expression of HIF-1α in normal brain tissues, but there was significant difference in the expression of HIF-1α in different groups （Х^2 = 40. 26, P 〈 0. 01 ）. The positive rate of HIF-1α gradually increased with the increase of pathological grade of gliomas （r = 0. 6977, P 〈 0. 001 ）. The expression of HIF-1α in gliomas didn＇t relate with the patients＇age, gender, tumor size and location. Conclusion The expression level of HIF-1α can be a useful marker in predicting the biological features and the prognosis of gliomas.