STAT3在肝细胞癌中的研究进展

Advances in understanding the role of STAT3 in the pathogenesis of hepatocellular carcinoma

STAT3是STAT家族的成员,是重要的核转录因子.STAT3可以被HBV、HCV和各种癌基因蛋白激活,STAT/SOCS信号失调也可以导致STAT3激活.活化后可以调控下游基因的转录.异常活化的STAT3肝细胞癌(hepatocellular carcinoma,HCC)癌组织中明显过表达,可导致肝细胞恶性转化从而发生癌变.此外STAT3信号的激活与c-Myc、EGFR、TGF、survivin、VEGF失调有关,这与HCC的发生,发展有密切的联系.我们将概述STAT3在HCC中的重要作用,并就STAT3作为HCC治疗新的靶点的研究现状进行综述.

Signal transducer and activator of transcription 3 （STAT3） is an important nuclear transcription factor that, once activated, can regulate the transcription of target genes. STAT3 is overexpressed in hepatocellular carcinoma （HCC）. It has been demonstrated that STAT3 can be activated by HBV, HCV and diverse oncoproteins. The dysregulation of STAT/SOCS signaling also results in constitutive activation of STAT3. Aberrantly activated STAT3 can contribute to the malignant transformation of liver cells and result in the occurrence of HCC by inducing dysregulation of c-Myc, EGFR, TGF, survivin and VEGF. This paper summarizes the critical role of STAT3 in the pathogenesis of HCC and explores the possibility of using STAT3 as a target for HCC therapy.