放疗增效方中药配合三维适形放疗治疗Ⅲ期食管癌术后患者疗效观察

Complementary effect of Radiotherapy Zengxiao Fomular of traditional chinese medicine combining with three-dimensional conformal radiotherapy（3D-CRT） on postoperative patients with stage Ⅲ esophageal carcinoma

目的观察放疗增效方配合三维适形放疗对食管癌术后Ⅲ期患者疗效的影响。方法研究组42例，采用放疗增效方中药配合三维适形放疗，持续至放疗结束；对照组35例，行单纯三维适形放疗，未服用中药。两组治疗前后分别进行生存率、不良反应、卡氏评分评估。结果治疗后，研究组生存率高于对照组，研究组1、2和3年生存率分别为59．5％，45．2％和30．9％，而对照组分别为57．1％，40．0％和14．3％，但差异无显著性（P〉0．05）；研究组KPS评分显著高于对照组；对防治放疗引起的副反应如白细胞下降、消化道反应及皮肤反应方面，观察组优于对照组。结论放疗增效方中药可提高食管癌术后Ⅲ期患者三维适形放疗的生活质量，减轻毒副作用，可作为食管癌放疗的辅助用药。

Objective To observe the complementary effect of Radiotherapy Zengxiao Fomular of traditional chinese medicine combining with radiotherapy on postoperative patients with stage Ⅱ esophageal carcinoma. Methods Forty-two case in Radiotherapy Zengxiao Fomular group received Radiotherapy Zengxiao Fomular that persistently used throughout the 3D-CRT. Thirty-five cases in control group received radiotherapy only. All cases had examination on survival rate, side effects, Kanofsky scores before and after treatment. Results The one year, two year and three year survival rate for patients in Radiotherapy Zengxiao Fomular group were 59. 5% ,4 5.2% and 30. 9% ,respectively,and those were 57.1% ,4 0.0% and 1 4. 3% in the control group. However, there was no significant difference （ P 〉 0. 05 ）. Radiotherapy Zengxiao Fomular group were better than the control group at Kanofsky scores, side effects such as white blood cell decrease, digestive reaction and skin function. Conclusion Radiotherapy Zengxiao Fomular can improve quality of life and relieve toxicity and side effects of postoperative patients with stage Ⅲ esophageal carcinoma. It is an ideal assistant medication in esophagus cancer radiotherapy.