摘要
目的探讨冠心病患者血小板活化膜糖蛋白GpⅡb／Ⅲa、P-selectin（P-选择素）的变化及其与高敏C反应蛋白（hs—CRP）的关系。方法用三色全血流式细胞术测定40例冠心病患者外周血中血小板GPUb／Ⅲa、P-selectin的表达水平，并检测患者hs—CRP水平，与30例健康对照者比较。结果冠心病组GpⅡb／Ⅲa、P—selectin、hs—CRP均高于健康对照组（均P〈0．001）。冠心病组GPⅡb／Ⅲa与hs．CRP呈正相关（r=0．45，P〈0．005），P-selectin与hs—CRP呈正相关（r=0．59，P〈0．001）。结论冠心病患者血清hs-CRP增加、血小板明显活化，其血小板活化程度与hs-CRP关系密切。
Objective To investigate the relationship among platelet membrane glucoproteins （ GP Ⅱb/Ⅲa and P-selectin） and hs-CRP in patients with coronary artery disease. Methods Subjects were divided into 2 groups （40 patients with coronary artery disease,30eases of healthy subjects）. Positive rates of PAC-1 and P- selectin were measured with tricolor flow cytometry. Hemorrheology was determined, and positive rates of GPⅡb/Ⅲa and P-selectin were measured with tricolor flow cytometry. Hs-CRP levels were measured by nephelometry and turbidimetry in patients and normal controls. Results Compared with healthy group, hs-CRP levels and the expressions of both GPⅡb/Ⅲa,P-selectin were increased significantly in patients with coronary artery disease （all P 〈0. 05 ）. There is a positive correlation between the GPⅡb/Ⅲa,P-selectin and hs-CRP in patients with coronary artery disease. Conclusion The platelet in patients with coronary artery disease is at the overactivated state. Hs-CRP is involved in coronary artery disease. There is a relation between platelet activation and systemic inflammation in patients with coronary artery disease.
出处
《中国临床实用医学》
2010年第9期86-87,共2页
China Clinical Practical Medicine
