职业社会心理因素及β1-AR Arg389Gly基因多态性与原发性高血压的交互作用

Analysis on effect of interaction between β1-AR Arg389Gly polymorphism and occupational social psychic factors on pathogenesy of essential hypertension

目的探讨β1-肾上腺素能受体(β1-AR)Arg389G ly多态性及与职业社会心理因素的交互作用对原发性高血压的影响。方法采用以职业紧张高暴露的男性列车行车人群为基础的1∶1配对病例对照研究(115对),通过问卷调查职业紧张、焦虑、抑郁、A型行为等职业社会心理因素及高血压的常见危险因素,应用PCR-RFLP技术检测β1-AR Arg389G ly多态性,通过多因素Logistic回归模型方法进行基因-环境的交互作用危险性分析。结果携带(Arg/G ly+G ly/G ly)基因型者与Arg/Arg基因型相比,其调整后OR达1.351;A型行为、特质焦虑、高"紧张反应"与Arg389G ly易感基因型同时存在的调整后OR分别达8.120、5.627和2.733。结论β1-AR Arg 389G ly可能是EH的遗传易感因素,但不是本研究人群EH的主要危险因素;职业社会心理因素与β1-AR Arg389G ly遗传因素间的环境-基因交互作用可能在EH的发病中发挥重要作用,且与职业人群的职业特点及个性、情绪因素密切相关。

Objective To explore the effect of interaction between adrenergic receptor（β1-AR）Arg389Gly polymorphism and occupational social psychic factors on the pathogenesy of essential hypertension（EH）.Methods Case-control study with 1：1 matched subject was performed in the study.One hundred and fifteen couples from the high occupational stress exposed male conductors working in the train,were selected as the objects.The occupational social psychic factors such as occupational stress,anxiety,depression,type A behavior etc.were evaluated by a proper questionnaire,meanwhile,the polymorphism of the adrenergic receptor Arg389Gly was detected by PCR-RFLP,the interaction between the occupational social psychic factors and gene polymorphism was analyzed by multiple factor logistic regression model.Results Compared to Arg/Arg genotype,persons with Arg/Gly or Gly/Gly genotype showed an increased risk of EH,and the adjusted OR was 1.351.The adjusted OR of persons with the mutational genotype of Arg389Gly and simultaneously possessed type A behavior,trait anxiety or high stress reaction were 8.120,5.627 or 2.733,respectively.Conclusions The results showed that the polymorphism of Arg 389Gly of β1-AR might be one of the crucial risk factor of EH,while the occupational social psychic factors could potentiate this effect of gene on EH.There may be an interaction between β1-adrenergic receptor polymorphisms and occupational social psychic factors in EH.