化放疗、放疗和化疗治疗肺癌脑转移的疗效评价

Evaluation of Curative Effects of Chemotherapy plus Radiotherapy, Radiotherapy alone or Chemotherapy alone in Treating lung Cancer with Brain Metastasis

目的评价化放疗、放疗和化疗治疗肺癌脑转移的疗效。方法化疗加放疗32例，放疗19例，化疗11例。结果化放疗组、放疗组和化疗组的中位生存期分别为6．9月、5．8月、3．6月；1年生存率分别为28．1％、21．1％、0％。化放疗组的疗效虽稍优于放疗组，但在统计学上差异无显著性（P＞0．05）。而化放疗组及放疗组明显好于化疗组（P＜0．05）。结论化放疗及放疗特别是化放疗是治疗肺癌脑转移的有效治疗方案。

Objective To evaluate the curative effect of chemotherapy plus radiotherapy, radiotherapy alone or chemothererapy alone in the treatmetn of lung cancer with brain metastasis . Method Sixty-two cases of lung cancer with brain metastasis were divided into three groups: ①32 patients treated with chemotherapy plus radiotherapy, ②19 patients with radiotherapy alone and ③11 patients with chemotherapy alone. Results The median survival period of three groups were 6. 9 months, 5.8 months and 3.6 months respectively. The 1- year survival rates of three groups were 28.1%,21. 1% and 0%separately. This study shows that the curative effect of chemotherapy plus radiotherapy is a little betterthan that of radiotherapy, but without statistical difference (p> 0.05). In addition, the curative effect of the two groups is much better than ahat of chemotherapy alone (P < 0.05). Conclusion Chemotherapy plus radiotherapy and radiotherapy can be considered as two efficacious regiments for lung cancer with brain metastasis, but the former in particular is efficacous.