正常血浆与正常全血在凝血过程中物理性能的差异

Differences of Physical Properties in the Course of Coagulation Between Normal Plasma and Normal Whole Blood

针对用旋转粘度计在恒定低切变率下测定抗凝血样复钙后的切应力随时间而变化的曲线,研究凝血状态检测和抗凝血药物的方法,提出了一种血液流变学理论模型,把血样看作非线性Maxwell流体,其物理性能(弹性模量和粘度等)都随凝血过程中结构的演化而变化.应用理论模型拟合实验结果,找出正常血浆与正常全血在低切变率下凝血过程中物理性能的差异.结果表明,正常血浆较正常全血的凝血过程慢,其粘度和屈服应力明显小,其凝固体的弹性却稍大.

Based on the curve（the shear stress versus the time） of an anticoagulative blood sample after recalcification under a constant low shear rate in a rotational viscometer is proposed,a hemorheological model is proposed to analyze blood coagulaltion and anticoagulative drugs.When the blood is considered as a nonlinear Maxwell fluid,the elastic modulus and viscosity vary with the evolution of microstructure during blood clotting.The experiment results are fitted by using hemorheological model,and the differences in parameters of the hemorheologlcal model between normal plasma and normal whole blood are found.The results show that the coagulation speed,yield stress and viscosity of normal plasma are much less than those of normal whole blood.Moreover,elastic modulus of normal plasma coagulation is a little bigger than those of normal whole blood