140例痰浊阻遏型高脂血症患者临床分类及血液流变学结果的分析

140 Cases of Phlegm Obstruction Type Hyperlipidemia:Clinical Classification and Hemorheological Analysis

目的通过分析140例痰浊阻遏型高脂血症患者临床分类及其血液流变学的结果,探讨痰浊阻遏型高脂血症中医证候特点。方法对临床辨证为痰浊阻遏型的140例高脂血症患者的血脂和血液流变学进行检测,分析高胆固醇血症、混合型高脂血症、高甘油三酯血症和低高密度脂蛋白血症患者血脂的特点及血液流变学的变化,对其相关性进行分析。结果 140例痰浊阻遏型高脂血症中,低HDL-C血症所占的比例最大,其次是混合型高脂血症,高TG血症次之,高TC血症所占的比例最小;高TG血症和混合型高脂血症TG水平和高TC血症TC显著高于其他各型(P<0.01),低HDL-C血症HDL-C显著低于其余各型(P<0.01),其余指标各型之间未见显著性差异(P>0.05);高TC血症和混合型高脂血症LDL-C水平显著高于其余各型(P<0.01),ApoAl、ApoB、ApoAl/ApoB各型之间未见显著性差异(P>0.05);混合型高脂血症血液流变学各项指标高于其它各型(P<0.01),其次是高TG血症(P<0.05)。结论痰浊阻遏型高脂血症多见于低HDL-C血症,混合型高脂血症血液流变学各项指标变化最明显。

Objective To explore the TCM characteristics on phlegm obstruction type hyperlipidemia by clinical classification and hemorheological analysis on 140 patients.Methods Blood samples,attained from the 140 patients diagnosed hyperlipidemia of phlegm obstruction type,were tested on blood lipids and hemorheology for analysis on characteristics and hemorheological changes of the following four subsets as hypercholesteremia,mixed hyperlipidemia,hypertriglyceridemia and low high-density lipoproteinemia,of which relevancies among the four were then analyzed.Results In the 140 cases,the low high-density lipoproteinemia took up the largest proportion,then the mixed hyperlipidemia ranked the second,then the hypertriglyceridemia,and the hypercholesteremia took up the smallest.Total cholesterol（TC） level in hypercholesteremia and triglyceride（TG） level in mixed hyperlipidemia were significantly higher than that in other subsets（P〈0.01）.HDL-C level was obviously lower in low high-density lipoproteinemia than that in other subsets（P〈0.01）.The rest indexes were observed no significant differences（P〉0.05）.LDL-C levels in hypercholesteremia and mixed hyperlipidemia were significantly higher than the rest subsets（P〈0.01）.Comparisons on ApoAI,ApoB,ApoAI/ApoB showed no significant differences among subsets（P〉0.05）.The hemorheological indexes in mixed hyperlipidemia were greater than other subsets（P〈0.01）,in which hypertriglyceridemia was greater than the rest（P〈0.05）.Conclusion Phlegm obstruction type hyperlipidemia is largely seen in low high-density lipoproteinemia.And the mixed hyperlipidemia has most significant hemorheological changes.