骨硷性磷酸酶对小儿佝偻病诊断价值的研究

Studied on diagnostic value of BALP in children rickets

目的为评价骨硷性磷酸酶（ＢＡＬＰ）在小儿佝偻病诊断上的实用与推广价值，并找出该方法实施的适宜检测人群，提高检测效益。方法我们对２８名０～３岁可疑佝偻患儿全部进行了ＢＡＬＰ检测并对其中部分患儿完成了血钙、磷、总硷性磷酸酶的测定，对其结果进行统计学分析计算出灵敏度、特异度、准确度、预测值、误诊率、漏诊率。结果当骨硷性磷酸酶值≥２００时其灵敏度为７５６３％，特异度为７７４２％，其阳性预测值达８３４％，当佝偻病患病率为５０～６０％时其灵敏度、阳性预测值及阴性预测值均超过了７０％。

Objective To evaluate the diagnostic value of bone alkaline phosphate(BALP) in children rickets. Methods Serum BALP levels were measured in 228 children (below 3 years old) with suspicious rickets. Serum Ca, P and total ALP were also measured in some subjects. All deta were analysed statistically for sensitivity. specificity. predictability and mid diagnosis rate.Results When BALP were greater ot equal to 200, the diagnostic sensitivity,specificity and postive predictability were 75.63%, 77.42% and 83.4% respectively. When incidence rate of rickets was 50～60%, the positive and negative predictability were more than 70%. Conclusion It suggests that BALP determination is a valuable method in diagnosis of children rickets.