葡萄糖酸锌辅助治疗轮状病毒肠炎42例

42 Cases of Rotaviral Enteritis Adjusted Treatment with Zinc Gluconate

目的探讨轮状病毒肠炎患儿补锌辅助治疗的疗效及对儿童短期内再发腹泻的影响。方法将82例轮状病毒肠炎患儿分为治疗组42例,对照组40例。对照组给予常规治疗,治疗组在常规治疗的基础上加服葡萄糖酸锌颗粒20mg.d-1,连续治疗14d。出院后3个月内随访再次发生腹泻情况。结果治疗组临床发热、呕吐和腹泻的持续时间分别为(3.58±0.98),(2.97±0.98),(5.23±0.85)d;对照组分别为(4.89±1.34),(4.46±1.85),(6.46±1.40)d(均P<0.01)。治疗组和对照组总有效率分别为95.2%,77.5%(P<0.01)。随访期内治疗组再发腹泻5例(11.9%),对照组再发腹泻14例(35.0%)(χ2=16.98,P<0.01)。结论在常规治疗的基础上加用锌剂可提高儿童轮状病毒肠炎的疗效,同时可以在短期内预防腹泻的再次发生。

Objective To explore the therapeutic effect of zinc supplementation on children with rotavirus enteritis and short-term recurrence of diarrhea. Methods A total of 82 children with rotavirus enteritis were divided into treatment group of 42 patients,and control group of 40 ones.The control group was given conventional therapy,the treatment group was given oral zinc gluconate granules 20 mg·d-1 for 14 days on the basis of conventional therapy,and they were followed up of recurrence of diarrhea after 3 months of discharge. Results The duration of fever,vomiting ,and diarrhea in the treatment group were significant shorter than those of the control group（3.58±0.98）,（2.97±0.98）,（5.23±0.85）,（4.89±1.34）,（4.46±1.85） and （6.46±1.40） days,respectively（P0.01）.The total efficiency of treatment group were significant higher than that of the control group（ 95.2%,77.5% respectively,P0.01）.The recurrence in treatment group （5 cases,11.9%） was significant lower than that of the control group（14 cases,35.0%）,（χ2=16.98,P0.01）. Conclusion Zinc supplementation could improve curative effect in children with rotavirus enteritis,and prevent the short term recurrence of diarrhea.