吸入4%高渗盐水诱导痰液在哮喘中的应用

The Application of Inhaling 4％ Saline in Asthmatic Sputum Induction

为建立一种痰液诱导的方法。采用哮喘患者雾化吸入4％高渗盐水30min诱导痰波，结果：哮喘发作期患者的第一秒末用力呼气容积（FEV1）及第一秒末用力呼气容积在用力呼气容积中的比值（FEV1／FVC）较基础值有轻度下降，但所进行的62人次的诱导中，有61人次产生了足量的痰液，诱导痰中鳞形细胞所占百分比在哮端发作期、缓解期患者及正常对照者分别为4．55％、5．49％和5．30％。结论：本研究所建立的痰液诱导的方法具有可行性、安全性和可靠性，是无创性研究哮喘气道炎症的一种有效方法。

To develop a new method of sputum induction, asthmatics were instructed to inhale 4% sterile nebulised saline. The success rate, safety and validity of sputum induction were determined. The results indicated that sputum induction is safe, valid, and it may be useful in studying asthma or other pulmonary diseases.