艾灸抗小鼠S_(180)实体瘤的实验研究

Experimental Study of the Antineoplastic Effect of Moxibustion

本实验建立Ｓ_（１８０）实体瘤小鼠模型，观察艾灸的抗肿瘤作用。实验表明，艾灸“关元”穴和对肿瘤的灸割治疗均能提高其存活率，延长生存期，抑制肿瘤的生长，有 ３３％以上的瘤重抑制率。灸疗能恢复与提高荷瘤小鼠对 ＣｏｎＬＡ（刀豆球蛋白 Ａ）、ＬＰＳ（脂多糖）诱导的脾淋巴细胞增殖反应及ＩＬ－１（白介素－１）、ＩＬ－２（白介素－２）的活性。上述指标与对照组相比均有显著性差异，且相当或优于环磷酰胺的抑瘤效果。表明灸疗有明显的抗肿瘤作用。实验结果提示，灸疗的抗肿瘤作用与其热疗效应、活血化瘀作用及提高机体免疫力等有密切关系。

S_(180) solid tumor models in mice were established to observe the antineoplastic effects of moxibustion. The study shows that the moxibustion on the point of 'Guanyuan' and cutting into the subcuta- neous tissue with surgical knife blade after moxibustion on the location of the tumor could hinder the growth of the tumor, thus heightened the survival rate and prolonged the duration of life of the mice. A more than 33 % rate of inhibition in treating the tumor was gained. It is also showed that the therapy improved the proliferative reaction of the splenic lymphocyte induced by the ConA and LPS, and improved the activity of IL-1 and IL-2. All these effects have statistical significance as compared with that of the control group, and were equal or superior to that of cyclophosphamide(CY). The results indicate that the thermotherapeutic effect, the effect of eliminating the stagnation and activiting the blood, the heightening of the immune function may all play a role in the moxibustion's antineoplastic effects.