BNP对AECOPD患者预后的评估作用

Role of BNP in evaluating prognosis of patients with AECOPD

目的研究BNP(B型钠尿肽)对AECOPD(慢性阻塞性肺病急性加重期)患者预后的评估作用。方法对AECO-PD患者进行BNP检测,用BNP水平预测患者收住ICU(重症监护病房)的需要以及1年内的死亡率。结果 COPD患者急性加重期的BNP水平比稳定期明显升高,需要收住ICU治疗的患者BNP水平比无须收住ICU的患者明显升高。多元Cox回归分析BNP能准确地预测患者收住ICU的需要。用ROC曲线评价BNP水平对AECOPD患者短期(1月)和长期(1年)死亡率的预测能力,ROC曲线下面积分别为0.54和0.55。结论对于AECOPD患者,BNP能独立预测患者收住ICU的需要,但不能预测患者短期和长期的死亡率。

Objective To study the role of BNP（B-type natriuretic peptide）in evaluating prognosis of patients with AECOPD（acute exacerbation of chronic obstructive pulmonary disease）.Methods BNP levels were tested in patients with AECOPD for predicting the needs to stay in ICU（intensive care unit）and the mortality within one year.Results BNP levels were higher in patients with acute exacerbation than those in patients with recovery.BNP levels in patients needed to stay in ICU were higher than those did not.BNP could predict the needs of ICU stay in Multiple Cox Regression analysis.The area under the ROC curve were 0.54 and 0.55 respectively evaluating the ability of BNP to predict short-term（one month）and long-term（one year）mortality with ROC curve.Conclusion For patients with AECOPD,BNP can independently predict the needs for ICU stay but can not predict short-term and long-term mortality.