左卡尼汀对COPD缓解期患者Leptin,CRP及IL-6产生的影响

Effect of L-carnitine on blood plasm Leptin,CRP and IL-6 in chronic obstructive pulmonary disease catabasis patients

目的探讨左卡尼汀对慢性阻塞性肺病(COPD)缓解期患者瘦素(Leptin),C反应蛋白(CRP)及白介素6(IL-6)产生的影响。方法 COPD缓解期患者51例随机分成两组(A组和B组),A组26例,平均年龄(62.52±4.38)岁,给予左卡尼汀口服溶液(1g/支)口服,每周3次;B组25例,平均年龄(63.38±6.47)岁,未予左卡尼汀治疗,总观察时间为8周,C组18例,为年龄、性别匹配的对照组.检测肝功能,肾功能,血脂,生化指标,肺功能,Leptin,CRP及IL-6水平并比较分析。结果 A、B两组患者研究前后血浆Leptin,CRP及IL-6水平均明显高于对照组(P<0.01和P<0.05);A组治疗前后Leptin,CRP及IL-6水平比较,差异具有显著性(P<0.01)。结论左卡尼汀降低COPD缓解期患者Leptin,CRP及IL-6水平,改善患者慢性炎症状态。

Objective To investigate the effect of L-carnitine on blood plasm Leptin,C reactive protein（CRP）and interleukin-6（IL-6）in chronic obstructive pulmonary disease（COPD）catabasis patients.Methods 51 COPD catabasis patients were randomly divided into two groups（A group,n=26 and B group,n=25）.Group A,aged（62.52±4.38 years）,1g of L-carnitine was taken orally three times every week,while group B,aged（63.38±6.47 years）did not receive L-carnitine.The total observation period was 8 weeks.18 age and sex matched volunteers served as control（Group C）.Hepatic function,renal function,blood-fat,blood plasm biochemical parameters,lung function,Leptin,CRP and IL-6 were measured and analyzed.Results Before and after the observation,levels of leptin,CRP and IL-6 in blood plasm which in the group A and group B were higher than the control（P〈0.01 and P〈0.05）;compared to after the treatment,levels of Leptin,CRP and IL-6 in blood plasm in the group A were significantly different t（P〈0.01）.Conclusion L-carnitine can decrease levels of Leptin,CRP and IL-6 in COPD catabasis and relieve the chronic inflammation state.