NDRG1在非小细胞肺癌中的表达及其与PTEN表达的相关性

Expression of NDRG1 in non-small cell lung cancer and its relatioship with expression of PTEN

目的研究NDRG1在非小细胞肺癌(NSCLC non-small cell lung cancer)中的表达、意义及其与PTEN表达的相关性。方法应用免疫组化方法检测69例NSCLC组织标本中和26例癌旁正常肺组织中NDRG1、PTEN的表达,分析NDRG1的表达与患者临床病理特征的关系及与PTEN表达的相关性。结果 NDRG1在NSCLC、癌旁正常肺组织中的阳性表达率分别为76.81%、7.69%,NSCLC中NDRG1的表达与分化程度、组织学类型、TNM分期、淋巴结转移相关(P<0.05),而与性别、年龄无关(P>0.05);NSCLC中NDRG1和PTEN表达呈负相关(rs=-0.381,P<0.05)。结论 NSCLC中存在NDRG1的高表达,与PTEN的低表达在NSCLC的发生发展过程中共同发挥着重要的作用。

Objective To study the expression of NDRG1 in NSCLC and its relationship with expression of PTEN,and to discuss their significance in carcinogenesis and progression of NSCLC.Methods The expression of NDRG1 and PTEN in 69 cases of NSCLC tissue and 26 cases of normal lung tissue were examined by immunohistochemistry.The relationship with expression of NDRG1 and various clinicopathologic parameter and expression of PTEN was analyzed.Results The positive rates of NDRG1 in NSCLC and in normal lung tissue were 76.81% and 7.69%,respectively.The expression of NDRG1 was closely related to histological type,cell differentiation grade,TNM stage and lymph node metastasis of the NSCLC（P〈0.05）.A negative correlation was observed between the expression of NDRG1 and PTEN（P〈0.05）.Conclusion There is high-expression of NDRG1 in NSCLC.The increased NDRG1 expression and the decreased PTEN expression may play an important role during the occurrence and the development of NSCLC.