进展性脑梗塞治疗的临床研究

Clinical analysis of treatment on Progressive cerebral infarction with edaravone and Defibrase

目的探讨进展性脑梗塞的治疗方法。方法对我院62例进展性脑梗塞住院患者,随机分为治疗组和对照组各31例。治疗组应用常规治疗加用依达拉奉、降纤酶联合治疗;对照组常规应用阿司匹林、抗凝治疗;评价两组治疗前及治疗后3d、7d、14d、30d、的神经功能缺损评分和30d后疗效。结果治疗组基本痊愈率及有效率高于对照组(P<0.05),且起效快,不增加不良反应。结论依达拉奉、降纤酶联合治疗进展性脑梗死比常规应用阿司匹林、抗凝治疗效果更好,且较安全。

Objective To evaluate the efficacy and safety of the combined treatment of edaravone And Defibrase on Progressive cerebral infarction. Methods The cases of Progre.ssive cerebral infarction treated in our department from septemer, 2005to october, 2009 were divided randomly into treatment group（ n = 31 ） and control group （ n = 31 ）. The former was treated with edaravone And Defibrase, while the latter was treated with Antifreeze and aspirin. The scores of neurologic impairment were recorded before the treatment and 3, 7, 14, 30d after the treatment. The curative effects were evaluated at the 30th day. Results The treatment group had a significantly higher excellent rate and healing rate, lower side effect rate as compared with the control group （P〈 0.05）. Conclusion The combined therapy of Progressive cerebral infarction with edaravone and Defibrase is more effective and safer than that with Antifreeze and aspirin only.