柴胡加龙骨牡蛎汤治疗失眠症对照研究

A control study of bupleurum plus Longgu Ostreae decoction in the treatment of insomnia

目的 探讨柴胡加龙骨牡蛎汤治疗失眠症的临床疗效和安全性. 方法 将80例失眠症患者随机分为研究组与对照组各40例,治疗组应用柴胡加龙骨牡蛎汤治疗,对照组口服枣仁安神胶囊治疗.观察4周.于治疗前及治疗4周末采用自拟睡眠质量问卷评定睡眠质量,以睡眠质量问卷总分减分率判定临床疗效,并记录两组不良反应. 结果 治疗4周末,研究组总有效率为92.5%,对照组为70.0%,研究组显著高于对照组（χ2=6.646,P＜0.05）;治疗后两组均未发现不良反应. 结论 柴胡加龙骨牡蛎汤治疗治疗失眠症疗效确切,安全性高,能促进失眠症患者睡眠的发生,维持睡眠状态的持续,促进日间体力精力的恢复.

Objective To explore the clinical efficacy efficacy and safety of bupleurum plus Longgu Ostreae decoction in insomnia. Methods Eighty insomnia patients were randomly assigned to two groups of 40 ones each, treatment group were treated with bupleurum plus Longgu Ostreae decoction and control group took orally Zhaoren tranquilization capsule for 4 weeks. Before treatment and at the end of the 4th week sleep quality was assessed with the Self-made Sleep Quality Questionnaire （SSQQ）, clinical efficacy determined according to decrement rate of total score of the SSQQ, and adverse reactions of both groups were recorded. Results At the end of the 4th week, total effective rates were respectively 92.5% in the research and 70.0% in the control group, the former was significantly higher than the latter （x^2=6. 646, P〈0.05） ; both groups had no adverse reactions after treatment. Conclusion Bupleurum plus Longgu Ostreae decoction has definite therapeutic effect and higher safety on insomnia, can promote the development of sleep, maintain dormancy and promote the recovery of daytime body force and energy.