抗抑郁剂联合认知领悟疗法治疗强迫症对照研究

A control study of antidepressants plus cognitive-comprehensive therapy in obsessive-compulsive disorder

目的 探讨抗抑郁剂联合认知领悟疗法治疗强迫症的临床疗效. 方法 将60例强迫症患者随机分为两组,每组30例,两组均口服抗抑郁剂治疗,研究组联合认知领悟疗法治疗,观察6个月.于治疗前及治疗1个月、2个月、4个月、6个月末采用Yale-Brown强迫量表评定临床疗效. 结果 治疗后两组Yale-Brown强迫量表总分及强迫思维因子分均较治疗前有显著下降（P＜0.01）;研究组治疗各时段Yale-Brown强迫量表总分及强迫思维因子分均显著低于对照组（P＜0.05或0.01）.治疗6个月末研究组有效率为73.33%,对照组为43.33%,研究组疗效显著高于对照组（χ2=5.554,P＜0.05）. 结论 抗抑郁剂联合认知领悟疗法治疗强迫症疗效更显著,起效更快,显著优于单纯药物治疗.

Objective To explore the clinical efficacy of antidepressants plus cognitive-comprehensive therapy （CCT） in obsessive-compulsive disorder （OCD）. Methods Sixty OCD patients were randomized to two groups of 30 ones each, both groups took orally antidepressants, research group was plus CCT for 6 months. Clinical efficacies were assessed with the Yale-Brown Obsessive Compulsive Sacle （Y-BOCS） before treatment and at the end of the 1st, 2nd, 4th and 6th month. Results After treatment, the total and obsessional thoughts score of the Y-BOCS of both groups lowered more significantly compared with pretreatment （P〈0.01）; after treatment, those at all points were significantly lower in the research than in the control group （P〈0. 05 or 0.01）. At the end of the 6th month, effective rates were respectively 73.33% in the research and 43.33% in the control group, the former was significantly higher than the latter （x^2=5. 554, P〈0.05）. Conclusion Antidepressants plus cognitive-comprehensive therapy has better effect and takes effect more rapidly in the treatment of obsessive-compulsive disorder compared with antidepressants only.