22例嗜酸细胞增多性脑膜脑炎患者临床分析

The clinical feature analysis on 22 patients with eosinophilic meningaencephalitis

目的阐明广州管圆线虫所致嗜酸细胞增多性脑膜脑炎的临床特点。方法分析２２例嗜酸细胞增多性脑膜脑炎患者的临床表现、实验室和流行病学资料。结果临床特点为：①以疼痛为主诉，头痛和脊神经根刺激症状明显；②头痛剧烈而脑膜刺激征缺乏；③半数以上病人伴有嗜酸粒细胞性肺炎；④周围血像、脑脊液中嗜酸性粒细胞增高；⑤预后好，属自限性疾病。

Objective To illustrate the clinical features of eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis. Methods The clinical findings,the laboratory data and the epidemiological information were analysed in 22 patients with eosinophilic meningoencephalitis. Results The clinical features as follows:1)Pain was a chief complaint. Headache and irritation of the spinal nerve roots were sharp. 2)They had severe headache with mild meningeal signs 3) Over half of the patients had eosinophilic pneumonia at the same time. 4) Eosiphilia in the peripheral blood and eosinophilic pleocytosis were prominent.5) The prognosis was better and the course of the disease might be self limited. Conclusion Angiostrongylus cantonensis is one of the most common causes leading to eosinophilic meningoencephalitis.