利培酮合并丁螺环酮治疗精神分裂症对照研究

Comparative study of risperidone combined with buspirone in the treatment of schizophrenia

目的探讨利培酮合并丁螺环酮治疗精神分裂症的临床疗效及副反应。方法将72例精神分裂症患者随机分为研究组(利培酮合并丁螺环酮治疗)36例和对照组(利培酮单用治疗)36例,疗程均为8周,采用阳性和阴性症状量表(PANSS)评定疗效,采用副反应量表(TESS)及实验室检查评定各种副反应。结果研究组第1周末PANSS平均减分率较对照组降低更明显(P<0.05),其他各周末PANSS平均减分率降低相当。两组的副反应发生率分别为研究组11.11%,对照组22.22%,严重程度大多数为轻度,少数为中度。利培酮总用量研究组较对照组少。结论利培酮合并丁螺环酮治疗精神分裂症起效快,可减少利培酮药物反应,降低其治疗量。

Objective To explore the efficacy and side effects of risperidone combined with buspirone in treatment of patients with schizophrenia. Methods A total of 72 patients with schizophrenia were randomly divided into study group with risperidone combined with buspirone and control group with risperidone for the treatment of 8 weeks. They were as- sessed with Positive and Negative Symptom Scale （PANSS）, Treatment Emergent Symptom Scale （TESS） and laboratory for efficacy and side effects. Results The decreased score rate of PANSS was significant higher in study group at the 1 st weekend than that in control group, while the rates had no significant differences in other weekends. The rate of side effects was 11.11% in study group and 22.22% in control group. There were no severe side effects in study group with lower dosage of risperidone. Conclusion Risperidone combined with buspirone is effective in the treatment of schizophrenia with less side effects and lower dosage of risperidone.