喹硫平与氟哌啶醇治疗老年期痴呆精神行为症状的对照研究

A comparative study on quetiapine and haloperidol in the treatment of behavioral and psychiatric symptoms of senile dementia patients

目的比较喹硫平与氟哌啶醇治疗老年期痴呆患者精神行为症状(BPSD)的疗效、副反应及对认知功能的影响。方法将符合条件的60例老年期痴呆患者随机分为喹硫平组和氟哌啶醇组(各30例),治疗2个月。采用一般情况调查表(自编)、临床疗效评定量表(CGI)、阿尔茨海默病病理行为评分表(BEHAVE-AD)、简易智力状态检查(MMSE)、药物副反应量表(TESS)进行疗效、副反应和认知功能评估。结果两组有效率分别为85.67%和83.33%,无显著性差异(P>0.05)。两组BEHAVE-AD评分治疗前后比较均有显著差异(P<0.05,P<0.01),治疗结束后两组间BEHAVE-AD评分无显著差异(P>0.05)。治疗结束后MMSE评分喹硫平组较氟哌啶醇组高,有显著差异(t=2.24,P<0.05)。两组锥体外系副反应发生率比较有显著性差异(2=6.91,P<0.01)。结论喹硫平与氟哌啶醇对老年期痴呆精神行为症状疗效相似,但副反应小,对认知功能的影响优于氟哌啶醇,故喹硫平更适合于伴有精神行为症状的老年期痴呆患者的治疗。

Objective To compare the efficacy and side effects of quetiapine and haloperidol in the treatment of behavioral and psychiatric symptoms of senile dementia patients and their effects on cognitive function. Methods Sixty senile dementia patients were randomly divided into two groups receiving quetiapine or haloperidol respectively for 2 months. They were assessed by CGI , BEHAVE -AD, MMSE and TESS. Results After treatment, the total efficacious rate of quetiapine group and haloperidol group was 86.67% and 83.33%, no significant difference was found between two groups （ P 〉 0.05 ） . BEHAVE-AD scores of groups respectively, both significantly decreased （ P 〈 0.01, P 〈 0.05 ）, there was no significant difference between two groups at the end of treatment. After treatment, MMSE score of quetiapine group was significantly higher than that in haloperidol group（ t = 2.24 ,P 〈 0.05 ）. The rate of side effects was significantly different rate between two groups （ x2 = 6.91 , P 〈 0.01 ）. Conclusion Quetiapine and haloperidol have the same efficacy, but quetiapine is better on the cognition function than haloperidol with fewer side effects for the senile dementia patients, such quetiapine is more suitable to treat behavioral and psychiatric symptoms of senile dementia .