重组复制缺陷型腺病毒介导血管内皮细胞生长因子cDNA治疗大鼠缺血皮瓣
摘要
皮瓣移植是皮肤缺损创面覆盖的主要手段，而皮瓣缺血性坏死是临床上常见的并发症。其原因是动脉供血不足或静脉回流不畅或兼而有之，如何改善微循环、促进皮瓣愈合、提高皮瓣移植的成功率一直是整形外科研究的重要课题。近年来，生长因子转基因治疗在这一领域表现出广阔的前景。笔者用基因治疗的方法，将人血管内皮细胞生长因子（VEGF）cDNA通过腺病毒载体，局部注射于皮瓣远端、受区下及受区表面，
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2010年第8期736-738,共3页
Chinese Journal of Trauma
参考文献7
-
1Ishiguro N,Yabe Y,Shimizu T,et al.Basic fibroblast growth factor has abeneficial effect on the viability ofrandom skin flaps in rat.Ann Plast Surg,1994,32(4):356 -360.
-
2Pu LL,Ahmed S,Thimson JG,et al.Endothelial cell growth factor enhances musculocutaneous flap survival through the process neovascukarization.Ann Plast Surg,1999,42(3):306 -312.
-
3姚远,汪春兰,王帮河.复制缺陷型腺病毒载体介导的VEGF基因治疗大鼠缺血皮瓣的研究[J].中国基层医药,2007,14(10):1640-1642. 被引量：1
-
4Keck PJ,Hauser SD,Krivi G,et al.Vascular permeability factor,an endothelial cell mitogen related to PDGF.Science,1989,246(4935):1309-1312.
-
5Dvork HF,Brown LF,Detmar M,et al.Vascular permeability/vascular endothelial growth factor; microvascular hyperpermeability,and angiogenesis.Am J Pathol,1995,146(5):1029-1039.
-
6Hood JD,Meininger CJ,Ziche M,et al.VEGF upregulates ecNOS message,protein and NO production in human endothelial cell.Am J Physiol,1998,274(3pt2):1054-1058.
-
7Murohara T,Horowitz JR,Lilver M,et al.Vascular endothelial growth factor/Vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.Circulation,1998,97(1):99 -107.
二级参考文献4
-
1Tsur H, Daniller A, Strauch B. Veovascularization of skin flap:route and rimting. Plast Reconster Surg, 1980,66 ( 1 ):85-90.
-
2Ishiguro N, Yabe Y, Shimizu T,et al. Basic flbroblast growth factor has a beneficial effect on the viability of random skin flaps in rats. Ann Plast Surg, 1994,32(4) :356-360.
-
3Pu LL, Ahmed S,Thomson JG, et al. Endothelial cell growth factor enhances musculocutaneous flap survival through the progress of neo- vascukarization. Ann Plast Surg, 1999,42 (3):306-312.
-
4Pang Y, Lineaweaver WC, Lei MP, et al. Evaluation of the mechanism of vascular endothelial growth factor improvement of isehemic flap survival in rats. Plast Reconstr Surg,2003,112(2) :556-564.
-
1林春艳,辛丽亚,曹海燕.肺癌患者血清VEGF-C的临床意义[J].哈尔滨医科大学学报,2007,41(5):468-469. 被引量：1
-
2沈百欣,钱立新,张炜,杨杰,宋宁宏,张杰秀,邵鹏飞,徐郑,虞梅林,王震,王心如.VEGF和VEGF-C表达增加与前列腺癌进展的相关性研究[J].中华泌尿外科杂志,2006,27(S2):42-46. 被引量：7
-
3靳风烁,于茂生.肿瘤的转基因治疗[J].国外医学（泌尿系统分册）,1993,13(4):145-147.
-
4郜恒骏,萧树东.白细胞介素-2与消化道肿瘤的基因治疗[J].肿瘤,2001,21(2):145-148. 被引量：1
-
5张艳,宋鸿钊,杨秀玉.多药耐药基因与骨髓抑制的转基因治疗[J].现代妇产科进展,1996,5(4):357-361.
-
6靳风烁,于茂生.转基因治疗及其在泌尿系肿瘤的研究现状[J].国外医学（泌尿系统分册）,1994,14(1):1-3.
-
7张银汉.癌症的转基因治疗[J].国外医学情报,2002,23(4):35-35.
-
8潘剑.淋巴管生成与肿瘤转移[J].国外医学（口腔医学分册）,2002,29(3):154-156.
-
9杨修伟,曾庆黎.血管内皮细胞生长因子C及其受体3在结直肠癌转移中的作用[J].南昌大学学报（医学版）,2014,54(7):92-95. 被引量：1
-
10安丽文,刘永军,赵丹懿,徐惠绵,关一夫.胃癌组织VEGF-C和CXCR4的表达与淋巴结转移的关系[J].世界华人消化杂志,2007,15(18):2026-2030. 被引量：5
