鼻咽癌患者生存质量量表的效度信度评价

Evaluating the validity and reliability of quality of life among nasopharyngeal carcinoma patients

目的:对研发的鼻咽癌(NPC)患者生存质量量表(QOL-NPC)进行信度和效度评价。方法:2007-01-21-2007-02-07,统一受训的调查员对433例确诊的、接受放疗的NPC患者进行调查,并采用相关分析、信度分析、因子分析和结构方程模型等统计方法进行分析。结果:QOL-NPC量表具有较好的分半信度和内部信度;除社会领域外(信度系数为0.628),各领域的内部信度系数均>0.8。每条目跟所属领域的相关系数>0.547,均有统计学意义,大于该条目与其他领域的相关系数,说明QOL-NPC量表有良好的内容效度。所有条目提取的6个主成分分布代表了各个领域,累计贡献达57.04%;结构方程模型拟和效果好,各条目和相关领域关系与量表的理论结构假设基本一致,结构效度较好。不同性别、不同放疗阶段患者的PS领域得分差异有统计学意义(t=2.10,P=0.037;F=3.34,P=0.019),不同收入人群的PH、PS、SE领域得分差异有统计学意义,P<0.05。结论:QOL-NPC量表有较好的信度和效度,可用于评价正在或者已经接受放疗NPC患者的生存质量。

OBJECTIVE：To evaluate the validity and reliability of quality of life among nasopharyngeal carcinoma patients （QOL-NPC）.METHODS：From 21 January to 7 February 2007,433 NPC patients who were being or had been treated by radiation were face-to-face interviewed with QOL-NPC by the well-trained investigators in Cancer Centre of Sun Yat-sen University.And then correlation analysis,reliability analysis,factor analysis and Structural equation model （SEM） were used to evaluate the scale.RESULTS：QOL-NPC had good split-half reliability and internal consistency.All the internal consistency Cronbach＇s coefficients were above 0.8,except for the domain of social function （its Cronbach＇s coefficient is 0.628）.The correlation between each item and its domain were more than 0.547,and they were statistically significant.What was more,they were greater than the correlation between the item and other domains.These demonstrated the QOL-NPC had good content validity and discriminatory validity.Six principal components extracted from all the items represented all domains of the scale and the cumulative variance was 57.04%.SEM showed that the constructs of the scale （the correlation between item and domain） obtained were consistent with the conceived concept in essence.It had good construct validity.The PS score of NPC patients among different gender and different radiation stage were statistically different （t=2.10,P=0.037;F=3.34,P=0.019）.The PH,PS and SE score of NPC patients among different income were statistically different （P〈0.05）.CONCLUSION：QOL-NPC has good reliability and validity,and it is available for the evaluation of quality of life among NPC patients who are being or has been treated by radiation.