卵巢上皮源性肿瘤Polo样激酶1的表达及其与p34cdc2的相关性

Expression of polo-like kinase1 in epitelial ovarian tumor and its correlation to p34cdc2

目的:探讨Polo样激酶1(plk1)、p34cdc2在卵巢上皮源性肿瘤组织中的表达及与卵巢癌各临床病理特征的关系。方法:免疫组化SP法对正常卵巢及卵巢上皮良性肿瘤、卵巢癌组织中的plk1、p34cdc2进行检测。结果:卵巢癌组织中的plk1、p34cdc2阳性表达率分别为80.8%(38/47)和63.8%(30/47)。plk1与p34cdc2的表达在正常卵巢、卵巢上皮良性肿瘤及卵巢癌组织中呈明显递增趋势,且两者在卵巢癌组织中的表达显著高于其余2组,P均<0.01。plk1的表达与卵巢癌的组织学分级、临床分期及病理学类型无关;p34cdc2的阳性表达与卵巢癌的组织学分级、临床分期呈明显相关。在47例卵巢癌组织中,plk1的表达与p34cdc2的表达呈正相关,r=0.388,P=0.004。结论:plk1和p34cdc2的高表达可能与卵巢癌的发生、发展密切相关,可望成为卵巢癌治疗的理想靶点。

OBJECTIVE：To check the expression of polo-like kinase1（plk1） and p34cdc2 in epithelial ovarian tumor,and analyze the Correlation between the expression of plk1,p34cdc2 and clinical pathological feature in epithelial ovarian carcinoma.METHODS：Immunohistochemistry was used to examine the expression of plk1 and p34cdc2 in nomal ovarian,benign epithelial ovarian tumor and epithelial ovarian carcinoma.RESULTS：The positive rate of plk1 and p34cdc2 in epithelial ovarian carcinoma were 80.8%（38/47） and 63.8%（30/47）.The expression of plk1 and p34cdc2 increased with nomal ovarian,benign epithelial ovarian tumor and epithelial ovarian carcinoma.The expression rates in epithelial ovarian carcinoma was remarkable higher than that in the others （P0.01）.There was no correlation between the expression of plk1 and clinical stage,the differentiated degree and the pathological type of the tumor.There was significant correlation between the expression of p34cdc2 and clinical stage and the differentiated degree,no correlation with the pathological type of the tumor.Significant positive correlation was found between the expression of plk1 and p34cdc2 in 47 cases of epithelial ovarian carcinoma （r=0.388,P=0.004）.CONCLUSION：The high expression of polo-like kinase1（plk1） and p34cdc2 is associated with the occurrence and development of epithelial ovarian carcinoma and may be the ideal targets for cancer therapy.