超声组织定征评价射频消融正常兔肝脏的实验研究

Experimental study on radiofrequency ablation normal rabbit liver by ultrasonic tissue characterization

目的:探讨超声组织定征技术评价射频消融正常兔肝改变的价值。方法:建立射频消融正常兔肝模型,分别于消融前、消融后1、3、5和15 d行二维超声及超声组织定征检查,二维超声观察肝脏消融后变化,超声组织定征定量分析消融灶改变。结果:射频消融后,二维超声显示高回声区类圆形病灶,其内相间弱回声;消融灶的超声组织定征平均强度、标准化IBS值均高于消融前,差异有显著性意义(P<0.05)。结论:射频消融正常兔肝的超声组织定征改变可以反映病理变化。

Objective： To explore the value of ultrasonic tissue characterization （UTC） in radiofrequency ablation （RFA） in normal rabbit liver. Methods： Animal models of RFA lesion normal liver were created. Ultrasonic examinations were performed at the times before and after the lesion of RFA at 1, 3, 5, 15 days. Results： The average image intensity and standard IBS（IBS%） of the normal rabbit liver were all higher than that before. The difference was significant （ p 〈0. 05）. IBS% could well correlate the pathological changes by RFA. Conclusion：The UTC heralds a new method of noninvasive quantitative measurement in the assessment of therapeutic response to radiofrequency ablation of the rabbit＇s normal liver.