摘要
目的:探讨胃癌超声造影的增强强度和胃癌病灶微血管密度(microvessel density,MVD)的相关性.方法:住院手术并有病理明确诊断的37例胃癌患者作为研究对象.术前进行超声造影检查,应用声学定量软件绘制胃癌病灶和癌旁正常胃壁的时间-强度曲线,定量分析超声造影的增强强度,术后病理标本应用抗CD34免疫组织化学法染色并检测肿瘤的MVD,分析胃癌病灶超声造影的增强强度和MVD的相关性.结果:37例胃癌病灶的增强强度高于癌旁正常胃壁(19.46±5.97vs14.25±2.55,P<0.01),胃癌病灶的MVD高于癌旁正常胃壁(84.68±37.99vs21.09±5.49,P<0.01),差异有统计学意义.胃癌病灶的增强强度和MVD呈正相关(r=0.77,P<0.01).结论:胃癌病灶的超声造影增强强度和MVD呈正相关,胃癌超声造影可以评价肿瘤新生血管生成和生物学行为.
AIM:To investigate the correlation between the enhanced intensity(EI) revealed by contrastenhanced ultrasonography(CEUS) and microvessel density(MVD) in gastric cancer.
METHODS:Thirty-seven patients who had pathologically confirmed gastric cancer and underwent CEUS were enrolled in this study.Parameters of the time-intensity curve(TIC),including peak intensity(PI) and basic intensity(BI) of gastric cancer and normal gastric wall,were analyzed.EI(EI = PI-BI) was then calculated.Immunohistochemical staining for CD34 was performed to evaluate MVD.The correlation between EI and MVD was then analyzed.
RESULTS:The EI in gastric cancer lesions was significantly higher than that in normal gastric wall(19.46 ± 5.97 vs 14.25 ± 2.55,P〈0.01).The MVD in gastric cancer lesions was also significantly higher than that in normal gastric wall(84.68 ± 37.99 vs 21.09 ± 5.49,P〈0.01).There was a positive linear correlation between EI and MVD in gastric cancer lesions(r = 0.77,P〈0.01).
CONCLUSION:EI is positively correlated with MVD in patients with gastric cancer.CEUS may be used for assessing the angiogenesis,biological behavior and prognosis of gastric cancer.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第20期2109-2113,共5页
World Chinese Journal of Digestology
基金
辽宁省教育厅2008年度高等学校创新团队计划基金资助项目
No.2008T210~~
关键词
胃癌
超声造影
增强强度
微血管密度
Gastric cancer
Contrast-enhanced ultrasonography
Enhanced intensity
Microvessel density