胃癌超声造影的增强强度和微血管密度的相关性

Correlation between intensity of ultrasonographic contrast enhancement and microvessel density in gastric cancer

目的:探讨胃癌超声造影的增强强度和胃癌病灶微血管密度(microvessel density,MVD)的相关性.方法:住院手术并有病理明确诊断的37例胃癌患者作为研究对象.术前进行超声造影检查,应用声学定量软件绘制胃癌病灶和癌旁正常胃壁的时间-强度曲线,定量分析超声造影的增强强度,术后病理标本应用抗CD34免疫组织化学法染色并检测肿瘤的MVD,分析胃癌病灶超声造影的增强强度和MVD的相关性.结果:37例胃癌病灶的增强强度高于癌旁正常胃壁(19.46±5.97vs14.25±2.55,P<0.01),胃癌病灶的MVD高于癌旁正常胃壁(84.68±37.99vs21.09±5.49,P<0.01),差异有统计学意义.胃癌病灶的增强强度和MVD呈正相关(r=0.77,P<0.01).结论:胃癌病灶的超声造影增强强度和MVD呈正相关,胃癌超声造影可以评价肿瘤新生血管生成和生物学行为.

AIM：To investigate the correlation between the enhanced intensity（EI） revealed by contrastenhanced ultrasonography（CEUS） and microvessel density（MVD） in gastric cancer. METHODS：Thirty-seven patients who had pathologically confirmed gastric cancer and underwent CEUS were enrolled in this study.Parameters of the time-intensity curve（TIC）,including peak intensity（PI） and basic intensity（BI） of gastric cancer and normal gastric wall,were analyzed.EI（EI = PI-BI） was then calculated.Immunohistochemical staining for CD34 was performed to evaluate MVD.The correlation between EI and MVD was then analyzed. RESULTS：The EI in gastric cancer lesions was significantly higher than that in normal gastric wall（19.46 ± 5.97 vs 14.25 ± 2.55,P〈0.01）.The MVD in gastric cancer lesions was also significantly higher than that in normal gastric wall（84.68 ± 37.99 vs 21.09 ± 5.49,P〈0.01）.There was a positive linear correlation between EI and MVD in gastric cancer lesions（r = 0.77,P〈0.01）. CONCLUSION：EI is positively correlated with MVD in patients with gastric cancer.CEUS may be used for assessing the angiogenesis,biological behavior and prognosis of gastric cancer.