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Nephrin与肾脏疾病的研究进展

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摘要 Nephrin是在裂孔隔膜上发现的第一个跨膜蛋白质，它主要由足细胞合成。它不仅是裂孔隔膜的关键结构分子，而且通过其磷酸化介导足细胞相关信号传导，参与足细胞的重要生物学功能。许多研究证实，nephrin的表达和分布改变是多种肾脏疾病的发病机制之一，缺乏nephrin可导致裂孔膜结构丧失、大量蛋白尿及肾衰竭。本文就近年来对nephrin与肾脏疾病的相关研究做一综述。
作者 王沛（综述） 纪泽泉（审校）
机构地区 广东省广州医学院第二附属医院儿科
出处 《临床肾脏病杂志》 2010年第8期383-384,F0003,共3页 Journal Of Clinical Nephrology
关键词 NEPHRIN 肾脏疾病 NEPHRIN 裂孔隔膜 相关信号传导 跨膜蛋白质 生物学功能 大量蛋白尿
分类号 R692 [医药卫生—泌尿科学]
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参考文献27

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二级参考文献18

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临床肾脏病杂志
2010年 第8期

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