VEGF在绝经后子宫内膜样腺癌中的表达及临床意义

The expression and significance of VEGF in postmenopausal endometrial adenocarcinoma

目的:探讨血管内皮生长因子(VEGF)在绝经后子宫内膜样腺癌中的表达及临床意义。方法:选择我院30例绝经后子宫内膜样腺癌组织和30例绝经后正常子宫内膜组织,应用免疫组织化学、原位杂交组织化学分别从细胞蛋白水平和分子基因水平检测VEGF在绝经后子宫内膜样腺癌组织的表达。结果:VEGF在绝经后子宫内膜样腺癌组织的表达显著高于正常子宫内膜组织(P=0.000);VEGF与组织学分级相关:其表达按高、中、低分化顺序升高(P=0.007,P=0.001);但与病理分期无关(P=0.160)。结论:VEGF在绝经后子宫内膜样腺癌高表达,参与绝经后子宫内膜样腺癌的肿瘤血管形成,可能在该疾病的早期发生和发展中发挥重要作用。

Objective：The aim of the study was to illustrate the expression of vascular endothelial growth factor（VEGF） and relationship with pathologic parameter in postmenopausal endometrial adenocarcinoma.Methods：Thirty patients with postmenopausal endometrial adenocarcinoma and thirty patients with normal endometrial tissue were enrolled in our study from April 2006 to April 2009 in our department. VEGF mRNA and protein levels were detected by in situ hybridization histochemistry（ISHH） and immunohistochemistry（IHC）.Results：VEGF expression were higher in postmenopausal endometrial adenocarcinoma than those corresponding normal tissue（P=0.000）;VEGF expression was positively correlated with pathologic grade（P=0.007） ,while not with FIGO stage（P=0.160）. There was correlation between the grade of tumour and VEGF overexpression（P=0.001）.Conclusion：Enhanced expression of VEGF may play a important role in tumor development and early growth of postmenopausal endometrial adenocarcinoma.