摘要
Three arylamide-bridged biscoumarin derivatives 1-3 have been designed and prepared. Compounds 1 and 2 are induced by the intramolecular N?H…O and N·H…F hydrogen bonding to possess a helical conformation,and 3 is induced to have an extended conformation. A comparison of their absorption and fluorescent spectra in a variety of solvents of a wide range of polarity with those of control compound 4 reveals that,for foldamers 1 and 2,the intramolecular hydrogen bonding and the helical conformations exist in most solvents,but do not exist or are very weak in DMF and DMSO.
Three arylamide-bridged biscoumarin derivatives 1-3 have been designed and prepared. Compounds 1 and 2 are induced by the intramolecular N-H…O and N-H…F hydrogen bonding to possess a helical conformation, and 3 is induced to have an extended conformation. A comparison of their absorption and fluorescent spectra in a variety of solvents of a wide range of polarity with those of control compound 4 reveals that, for foldamers 1 and 2, the intramolecular hydrogen bonding and the helical conforma- tions exist in most solvents, but do not exist or are very weak in DMF and DMSO.
基金
supported by the National Natural Science Foundation of China (20732007,20621062,20672137,20872167)
the National Basic Research Program of China (2007CB808001)
the Science and Technology Commission of Shanghai Municipality (09XD14-05300)
