人乳头瘤病毒和核因子κB与卵巢癌关系的研究进展

Research Advancement of HPV and NF-κB Expression in Epithelial Ovarian Carcinoma

高危型人乳头瘤病毒感染与多种上皮性恶性肿瘤的发生有关。它与卵巢癌的关系也已受到关注。人乳头瘤病毒致癌是一个多因素、多步骤的渐进过程,其中协同因素也发挥重要作用。核因子κB在连接慢性炎症和肿瘤的过程中发挥重要的作用,卵巢癌组织中核因子κB有很高的阳性表达。现对人乳头瘤病毒、核因子κB在卵巢癌中的研究进展予以综述。

Infection of high-risk human papillomaviruses can lead to the development of many epithelial cell carcinomas and its role in ovarian cancer has drawn more attention.The carcinogenesis of HPV is a multi-factor and multi-step process,in which genetic and synergistic factors also play an important role.NF-κB plays an important role in inflammation-associated cancer.The high expression of NF-κB has been found in epithelial ovarian carcinoma.This article reviews HPV and NF-κB in terms of the progress in the mechanism of epithelial ovarian carcinoma.