内毒素在中耳胆脂瘤骨质破坏机制中的作用

The Role of Endotoxin in the Mechanism of Bone Destruction Caused by Middle Ear Cholesteatoma

关于胆脂瘤骨质破坏的原因众说纷纭,近年来的研究认为内毒素在其骨质破坏中发挥重要的作用。内毒素引起骨质破坏的机制与以下两个方面有关:内毒素通过刺激局部巨噬细胞产生肿瘤坏死因子α和白细胞介素1等炎性细胞因子而引起骨质破坏;内毒素通过启动细胞核因子κB受体活化因子配体而诱导破骨细胞前提细胞产生大量的破骨细胞引起骨质破坏。

Now it has some different opinions on the bone destruction.Recent researches suggested that endotoxin in the bone destruction played an important role in its mechanism of bone destruction caused by the following two aspects：endotoxin by stimulating the local giant macrophage production of tumor necrosis factor-α,interleukin-1 and other inflammatory cytokines caused bone destruction;endotoxin by starting the nuclear factor-κB ligand receptor which induced osteoclast prerequisite activating a number of osteoclast cells caused bone destruction.