心脉隆注射液对急性心肌梗死患者脑钠肽的影响及其临床意义

The Effect and Clinical Siginificance of Xinmailong Injection on Plasma Brain Natriuretic Peptide in Acute Myocardial Infarction

目的探讨心脉隆注射液对急性心肌梗死患者脑钠肽(BNP)的影响及其临床意义。方法 112例患者随机分为2组,试验组59例,对照组53例。两组均按急性心肌梗死治疗指南进行处置,对照组患者接受抗血小板、抗凝、降脂、降压、扩张冠状动脉等方面治疗,试验组在此基础上加用心脉隆静脉滴注,每天2次,连续使用5d。将两组患者的血BNP浓度及预后进行比较。结果两组患者入院即刻血BNP浓度差异无统计学意义,第5天试验组血BNP浓度明显低于对照组(P<0.01);试验组并发症总发生率(12%)明显低于对照组(28%)(P<0.05),试验组心力衰竭4例(7%)、梗死后心绞痛2例(3%),与对照组分项比较差异显著。结论心脉隆注射液能有效降低急性心肌梗死患者脑钠肽的浓度,有效减少住院期间心脏事件的发生。

Objective To explore the effect and clinical siginificance of Xinmailong injection on plasma brain natriuretic peptide（BNP）in acute myocardial infarction（AMI）.Methods 112 cases with AMI were randomly divided into treatment group（group A,n=59）and control group（group B,n=53）.All patients who treated with anti-platelet,anticoagulation,therapies for lowering blood-lipids and blood pressure and dilatation of coronary artery underwent medicine therapy on AMI guideline,and the patients in group A were added Xinmailong injection which be used twice a day for five days,while the patients in group B without.The data of both groups were compared with BNP concentrations and prognosis.Results There was no significant difference（P0.05）in group A and B of BNP concentrations at admission,but was significant difference 5 days after hospitalization.The complication rate in group A（12%）was significantly lower than that in group B（28%）.In group A,there were 4 cases of heart failure（7%）and 2 cases of post-infarction angina pectoris（3%）.The above indexes were significantly different between A and B group.Conclusion It demonstrated that Xinmailong injection could decrease the level of BNP in AMI patients,as well as reduce cardiac events in hospital.