新疆331例HBV感染患者基因型及临床特征分析

Clinical characteristic and HBV genotype of HBV carriers in Xinjiang

目的探讨新疆慢性乙型肝炎病毒(HBV)感染者基因型分布情况和临床特征。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)的方法,分析2007年在新疆医科大学第一附属医院就诊的331例慢性HBV感染者基因型与临床特点。结果 331例慢性HBV感染者中,HBV B基因型占14.8%(49/331),C基因型占72.8%(241/331),C/D重组体占9.7%(32/331),D基因型占2.7%(9/331)。4种基因型中,C基因型所占比例明显高于B基因型、C/D重组体和D基因型。C基因型在乙型肝炎e抗原(HBeAg)阳性、慢性乙型肝炎(CH)、乙肝肝硬化(LC)、乙肝肝癌(HCC)患者中所占比例明显高于B基因型、C/D重组体、D基因型,差异均有统计学意义(P<0.05)。4种基因型在性别、谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBIL)、血清白蛋白(ALB)等方面比较,差异无统计学意义(P均>0.05)。结论新疆地区HBV感染者,HBV基因型以C基因型为主,慢性乙型肝炎C基因型病情重,预后差。

Objective To understand HBV genotype distributed and clinical characteristic by HBV infection disease.Methods HBV genotype distributed and clinical characteristic by HBV infection disease with HBV genotyping were analyzed by polymerase chain reaction（PCR）-restriction fragment length polymorphism.Results Of the 331 patients investigated in 2007,genotype B,C,C/D,D were accounted 14.8%（49/331）,72.8%（241/331）,9.7%（32/331） and 2.7%（9/331） respectively.In four HBV genotypes,C genotype had significant differences in age compared with B,C/D genotypes（P0.05）.C genotype age had significant differences compared with B,C/D,HBeAg,CH,LC,HCC（P0.05）.Sex,ALT,AST,TBIL,ALB had no significant differences in these four types（P0.05）.Conclusion The C genotype is main genotype in Xinjiang with chronic HBV infection.C genotype leads to patient′s condition severity.