^(131)I-组胺-吲哚美辛对大鼠Lewis肺癌的SPECT显像及疗效观察

Imaging and Effect of ^(131)I-histamine-indomethacin in SPECT for Rat's Lewis Pulmonary Tumor Model

观察了131I-组胺-吲哚美辛(131I-His-IN)对荷Lewis肺癌大鼠的SPECT显像及内照射治疗效果,为肿瘤诊断及治疗提供依据。以灌胃的方式给荷Lewis肺癌的模型鼠131I-His-IN,并对灌药后的荷瘤鼠行SPECT显像及病理观察。结果显示,肿瘤部位与肿瘤以外各显影区域的131I-His-IN放射性计数比随时间延长明显升高,即131I-His-IN在肿瘤区的相对停留时间较长;病理结果显示肿瘤坏死组织随时间推移而增多。以上结果表明,131I-His-IN具有诊断肿瘤原发灶、远处转移灶的作用,对肿瘤具有双重治疗的作用,是当前进行肿瘤诊断及治疗的一种有效方法。

In order to observe the Visualization of SPECT and therapeutic effect of 131I-histamine-indomethacin（131I-His-IN） in rat＇s Lewis pulmonary tumor model,rats with Lewis pulmonary tumor were gavaged with 131I-His-IN.The results showed that 131I-His-IN radioactive nuclide rate of tumor area to other area step up as the time goes by,and the necrotic tissue and cells become more and more.These suggested that 131I-His-IN was an effective imaging agent which can diagnosis the primarily focus and the distant place metastasis of the tumor and do the internal radiation of the tumor.