酪氨酸蛋白激酶受体c-Met及靶点药物研究进展

Research Progress on the Receptor Tyrosine Protein Kinase and Targeted Drugs

酪氨酸激酶受体c-Met在细胞的代谢、分化以及死亡细胞的信号传导过程中起着重要的作用,其与配体结合,可活化其信号通路,参与胚胎发育、组织损伤修复以及肿瘤的发生和发展。因而,以酪氨酸激酶受体c-Met为靶点的抗肿瘤药物已经成为肿瘤研究中十分活跃的领域,为抗肿瘤治疗提供了新方法。

The c-Met oncogene,encoding the receptor tyrosine kinase,plays an important role in the process of cellular metabolism,differentiation and signal transduction of cell death.HGF combine c-Met can induce activation of a series of signal pathway and stimulate embryonic development,repair tissue injury and development of tumor.Thus,anticancer drugs of therapeutic target of c-Met has become very active in the cancer research field and provides a new approach for anti-tumor therapy.