摘要
酪氨酸激酶受体c-Met在细胞的代谢、分化以及死亡细胞的信号传导过程中起着重要的作用,其与配体结合,可活化其信号通路,参与胚胎发育、组织损伤修复以及肿瘤的发生和发展。因而,以酪氨酸激酶受体c-Met为靶点的抗肿瘤药物已经成为肿瘤研究中十分活跃的领域,为抗肿瘤治疗提供了新方法。
The c-Met oncogene,encoding the receptor tyrosine kinase,plays an important role in the process of cellular metabolism,differentiation and signal transduction of cell death.HGF combine c-Met can induce activation of a series of signal pathway and stimulate embryonic development,repair tissue injury and development of tumor.Thus,anticancer drugs of therapeutic target of c-Met has become very active in the cancer research field and provides a new approach for anti-tumor therapy.
出处
《浙江海洋学院学报(自然科学版)》
CAS
2010年第3期273-278,共6页
Journal of Zhejiang Ocean University(Natural Science Edition)
基金
浙江省自然科学基金(Y2080579
Y2090678)
浙江海洋学院校级课题(21135030107
11132100409)