大鼠骨骼肌静力性负荷所致损伤过程中肌细胞能量代谢的变化

Changes of Energy Metabolism in the Skeletal Muscle of Rats in Injury Induced by the Dynamic Load

通过采用骨骼肌静力性负荷损伤动物模型,观察在所致损伤过程中肌糖原含量、骨骼肌线粒体ATP酶活性以及骨骼肌胞浆和血清中乳酸含量的变化,来探讨肌细胞能量代谢变化与骨骼肌静力性负荷所致损伤的关系。结果表明,肌细胞能源物质耗竭、能量供应不足以及糖类氧化不足所引起的三羧酸循环中介物缺乏并非导致骨骼肌静力性损伤的直接原因,肌细胞内乳酸等代谢产物堆积产生的毒副作用可能是引起骨骼肌静力性损伤的重要因素。

The animal model of injury induced by the dynamic load of skeletal muscle is used to observe changes of muscle glycogen, ATP activity of muscle mitochondria, cytoplasmic and lactic acid of serum of injury to discuss the relation between change of energy metabolism of skeletal muscle cell and injury induced by dynamic load of skeletal muscle. Results show that TAC resulting from energy material depletion, unbalanced energy supply and carbohydrate oxidative insufficiency is not the direct cause of injury of dynamic load and the important factor accounting for injury of dynamic load is likely to be the side - effect produced by metabolite accumulated through lactic acid of muscle cell.